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SMILES: CC(=O)Nc1nc2ccc(CCNC(=O)Nc3cc(c(Cl)cc3OCCN)C(F)(F)F)cc2[nH]1

InChI Key: InChIKey=KSKILNZOVOWXGN-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50340285   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
RAF proto-oncogene serine/threonine-protein kinase


(Homo sapiens (Human))		BDBM50340285
PNG
(CHEMBL1760736 | N-(6-(2-(3-(2-(2-aminoethoxy)-4-ch...)
Show SMILES CC(=O)Nc1nc2ccc(CCNC(=O)Nc3cc(c(Cl)cc3OCCN)C(F)(F)F)cc2[nH]1
Show InChI InChI=1S/C21H22ClF3N6O3/c1-11(32)28-19-29-15-3-2-12(8-16(15)30-19)4-6-27-20(33)31-17-9-13(21(23,24)25)14(22)10-18(17)34-7-5-26/h2-3,8-10H,4-7,26H2,1H3,(H2,27,31,33)(H2,28,29,30,32)
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Merck Serono

Curated by ChEMBL


Assay Description
Inhibition of human cRAF using [gamma-33P-ATP] as a substrate by scintillation counting

Bioorg Med Chem Lett 21: 2264-9 (2011)


Article DOI: 10.1016/j.bmcl.2011.02.108
BindingDB Entry DOI: 10.7270/Q2MS3T23
More data for this
Ligand-Target Pair