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SMILES: CNC(=O)c1cc2ccc(CCNC(=O)Nc3cccc(c3)S(=O)(=O)C(F)(F)F)cc2cn1

InChI Key: InChIKey=UPGDTCZNVAQHMJ-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50340288   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
RAF proto-oncogene serine/threonine-protein kinase


(Homo sapiens (Human))		BDBM50340288
PNG
(CHEMBL1760617 | N-methyl-7-(2-(3-(3-(trifluorometh...)
Show SMILES CNC(=O)c1cc2ccc(CCNC(=O)Nc3cccc(c3)S(=O)(=O)C(F)(F)F)cc2cn1
Show InChI InChI=1S/C21H19F3N4O4S/c1-25-19(29)18-10-14-6-5-13(9-15(14)12-27-18)7-8-26-20(30)28-16-3-2-4-17(11-16)33(31,32)21(22,23)24/h2-6,9-12H,7-8H2,1H3,(H,25,29)(H2,26,28,30)
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Merck Serono

Curated by ChEMBL


Assay Description
Inhibition of human cRAF using [gamma-33P-ATP] as a substrate by scintillation counting

Bioorg Med Chem Lett 21: 2264-9 (2011)


Article DOI: 10.1016/j.bmcl.2011.02.108
BindingDB Entry DOI: 10.7270/Q2MS3T23
More data for this
Ligand-Target Pair