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SMILES: COc1cc2ncnc(Oc3ccc(F)c(Cl)c3)c2cc1OC

InChI Key: InChIKey=FRTNWIZUWYFSFX-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50340917   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM50340917 (4-(3-chloro-4-fluorophenoxy)-6,7-dimethoxyquinazol...) Show SMILES COc1cc2ncnc(Oc3ccc(F)c(Cl)c3)c2cc1OC Show InChI InChI=1S/C16H12ClFN2O3/c1-21-14-6-10-13(7-15(14)22-2)19-8-20-16(10)23-9-3-4-12(18)11(17)5-9/h3-8H,1-2H3	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Univ. Lille Curated by ChEMBL					Assay Description Inhibition of human EGFR after 1 hr using [gamma-32P]ATP				Bioorg Med Chem 23: 7340-7 (2015) Article DOI: 10.1016/j.bmc.2015.10.035 BindingDB Entry DOI: 10.7270/Q2BZ67VR
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50340917 (4-(3-chloro-4-fluorophenoxy)-6,7-dimethoxyquinazol...) Show SMILES COc1cc2ncnc(Oc3ccc(F)c(Cl)c3)c2cc1OC Show InChI InChI=1S/C16H12ClFN2O3/c1-21-14-6-10-13(7-15(14)22-2)19-8-20-16(10)23-9-3-4-12(18)11(17)5-9/h3-8H,1-2H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	9.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
Univ. Lille Curated by ChEMBL					Assay Description Inhibition of human recombinant VEGFR-2 after 1 hr using [gamma-32P]ATP				Bioorg Med Chem 23: 7340-7 (2015) Article DOI: 10.1016/j.bmc.2015.10.035 BindingDB Entry DOI: 10.7270/Q2BZ67VR
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM50340917 (4-(3-chloro-4-fluorophenoxy)-6,7-dimethoxyquinazol...) Show SMILES COc1cc2ncnc(Oc3ccc(F)c(Cl)c3)c2cc1OC Show InChI InChI=1S/C16H12ClFN2O3/c1-21-14-6-10-13(7-15(14)22-2)19-8-20-16(10)23-9-3-4-12(18)11(17)5-9/h3-8H,1-2H3	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Univ. Lille Nord de France Curated by ChEMBL					Assay Description Inhibition of human EGFR expressed in human A431 cells using poly(Glu4/Tyr) and [gamma32P]ATP as substrate after 1 hr by scintillation counting				J Med Chem 55: 1189-204 (2012) Article DOI: 10.1021/jm2013453 BindingDB Entry DOI: 10.7270/Q2086695
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50340917 (4-(3-chloro-4-fluorophenoxy)-6,7-dimethoxyquinazol...) Show SMILES COc1cc2ncnc(Oc3ccc(F)c(Cl)c3)c2cc1OC Show InChI InChI=1S/C16H12ClFN2O3/c1-21-14-6-10-13(7-15(14)22-2)19-8-20-16(10)23-9-3-4-12(18)11(17)5-9/h3-8H,1-2H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	9.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
Univ Lille Nord de France, F-59000 Lille, France; UDSL, ICPAL, EA 4481, F-59006 Lille, France. Curated by ChEMBL					Assay Description Inhibition of recombinant human VEGFR-2-mediated poly(Glu4Tyr) phosphorylation after 1 hr				Bioorg Med Chem Lett 21: 2106-12 (2011) Article DOI: 10.1016/j.bmcl.2011.01.137 BindingDB Entry DOI: 10.7270/Q2C24WRV
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50340917 (4-(3-chloro-4-fluorophenoxy)-6,7-dimethoxyquinazol...) Show SMILES COc1cc2ncnc(Oc3ccc(F)c(Cl)c3)c2cc1OC Show InChI InChI=1S/C16H12ClFN2O3/c1-21-14-6-10-13(7-15(14)22-2)19-8-20-16(10)23-9-3-4-12(18)11(17)5-9/h3-8H,1-2H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	9.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
Univ. Lille Nord de France Curated by ChEMBL					Assay Description Inhibition of recombinant human VEGFR-2 using poly(Glu4/Tyr) and [gamma32P]ATP as substrate after 1 hr by scintillation counting				J Med Chem 55: 1189-204 (2012) Article DOI: 10.1021/jm2013453 BindingDB Entry DOI: 10.7270/Q2086695
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM50340917 (4-(3-chloro-4-fluorophenoxy)-6,7-dimethoxyquinazol...) Show SMILES COc1cc2ncnc(Oc3ccc(F)c(Cl)c3)c2cc1OC Show InChI InChI=1S/C16H12ClFN2O3/c1-21-14-6-10-13(7-15(14)22-2)19-8-20-16(10)23-9-3-4-12(18)11(17)5-9/h3-8H,1-2H3	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Univ Lille Nord de France, F-59000 Lille, France; UDSL, ICPAL, EA 4481, F-59006 Lille, France. Curated by ChEMBL					Assay Description Inhibition of human EGFR-mediated poly(Glu4Tyr) phosphorylation after 1 hr				Bioorg Med Chem Lett 21: 2106-12 (2011) Article DOI: 10.1016/j.bmcl.2011.01.137 BindingDB Entry DOI: 10.7270/Q2C24WRV
					More data for this Ligand-Target Pair