BDBM50341309 CHEMBL1766081::isopropyl 4-(5-methyl-6-(2-methylpyridin-3-yloxy)pyrimidin-4-yloxy)piperidine-1-carboxylate
SMILES: CC(C)OC(=O)N1CCC(CC1)Oc1ncnc(Oc2cccnc2C)c1C
InChI Key: InChIKey=YHKUMVXEUWUPKX-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
G-protein coupled receptor 119 (GPR119) (Homo sapiens (Human)) | BDBM50341309 (CHEMBL1766081 | isopropyl 4-(5-methyl-6-(2-methylp...) | UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 23 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc. Curated by ChEMBL | Assay Description Displacement of [3H]isopropyl 4-(1-(4-(methylsulfonyl)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yloxy)piperidine-1-carboxylate/tert-butyl 4-(1-(4-(methyl... | J Med Chem 54: 1948-52 (2011) Article DOI: 10.1021/jm200003p BindingDB Entry DOI: 10.7270/Q2CZ37G0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glucose-dependent insulinotropic receptor (Rattus norvegicus) | BDBM50341309 (CHEMBL1766081 | isopropyl 4-(5-methyl-6-(2-methylp...) | Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 140 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc. Curated by ChEMBL | Assay Description Displacement of [3H]isopropyl 4-(1-(4-(methylsulfonyl)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yloxy)piperidine-1-carboxylate/tert-butyl 4-(1-(4-(methyl... | J Med Chem 54: 1948-52 (2011) Article DOI: 10.1021/jm200003p BindingDB Entry DOI: 10.7270/Q2CZ37G0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glucose-dependent insulinotropic receptor (Rattus norvegicus) | BDBM50341309 (CHEMBL1766081 | isopropyl 4-(5-methyl-6-(2-methylp...) | Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 84 | n/a | n/a | n/a | n/a |
Pfizer Inc. Curated by ChEMBL | Assay Description Agonist activity at rat GPR119 expressed in human HEK293 cells assessed as increase in cAMP level after 16 hrs by beta-lactamase reporter gene assay | J Med Chem 54: 1948-52 (2011) Article DOI: 10.1021/jm200003p BindingDB Entry DOI: 10.7270/Q2CZ37G0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
G-protein coupled receptor 119 (GPR119) (Homo sapiens (Human)) | BDBM50341309 (CHEMBL1766081 | isopropyl 4-(5-methyl-6-(2-methylp...) | UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 7.30 | n/a | n/a | n/a | n/a |
Arena Pharmaceuticals Curated by ChEMBL | Assay Description Agonist activity at human GPR119 receptor assessed as cAMP production by HTRF assay | Bioorg Med Chem Lett 22: 1750-5 (2012) Article DOI: 10.1016/j.bmcl.2011.12.092 BindingDB Entry DOI: 10.7270/Q26H4HW1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
G-protein coupled receptor 119 (GPR119) (Homo sapiens (Human)) | BDBM50341309 (CHEMBL1766081 | isopropyl 4-(5-methyl-6-(2-methylp...) | UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 15 | n/a | n/a | n/a | n/a |
Merck Research Laboratories Curated by ChEMBL | Assay Description Agonist activity at human GPR119 expressed in HEK293 cells assessed as stimulation of cMAP level by cell-based cAMP assay | Bioorg Med Chem Lett 21: 3290-6 (2011) Article DOI: 10.1016/j.bmcl.2011.04.035 BindingDB Entry DOI: 10.7270/Q2W0967Q | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glucose-dependent insulinotropic receptor (Rattus norvegicus) | BDBM50341309 (CHEMBL1766081 | isopropyl 4-(5-methyl-6-(2-methylp...) | Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 83 | n/a | n/a | n/a | n/a |
Arena Pharmaceuticals Curated by ChEMBL | Assay Description Agonist activity at rat GPR119 receptor assessed as cAMP production by HTRF assay | Bioorg Med Chem Lett 22: 1750-5 (2012) Article DOI: 10.1016/j.bmcl.2011.12.092 BindingDB Entry DOI: 10.7270/Q26H4HW1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
G-protein coupled receptor 119 (GPR119) (Homo sapiens (Human)) | BDBM50341309 (CHEMBL1766081 | isopropyl 4-(5-methyl-6-(2-methylp...) | UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 14 | n/a | n/a | n/a | n/a |
Pfizer Inc. Curated by ChEMBL | Assay Description Agonist activity at GPR119 in human HEK293 cells assessed as increase in cAMP level after 16 hrs by beta-lactamase reporter gene assay | J Med Chem 54: 1948-52 (2011) Article DOI: 10.1021/jm200003p BindingDB Entry DOI: 10.7270/Q2CZ37G0 | |||||||||||
More data for this Ligand-Target Pair |