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BDBM50341371 6-(2,4-Difluorophenoxy)-8-methyl-2-methylamino-8H-pyrido[2,3-d]pyrimidin-7-one::CHEMBL1766573

SMILES: CNc1ncc2cc(Oc3ccc(F)cc3F)c(=O)n(C)c2n1

InChI Key: InChIKey=OZULYIIGBMRTMW-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50341371   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Mitogen-activated protein kinase 14


(Homo sapiens (Human))
BDBM50341371
PNG
(6-(2,4-Difluorophenoxy)-8-methyl-2-methylamino-8H-...)
Show SMILES CNc1ncc2cc(Oc3ccc(F)cc3F)c(=O)n(C)c2n1
Show InChI InChI=1S/C15H12F2N4O2/c1-18-15-19-7-8-5-12(14(22)21(2)13(8)20-15)23-11-4-3-9(16)6-10(11)17/h3-7H,1-2H3,(H,18,19,20)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

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DrugBank
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CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 260n/an/an/an/an/an/a



Roche Palo Alto LLC

Curated by ChEMBL


Assay Description
Inhibition of human recombinant p38alpha assessed as incorporation of 33P from gamma-[33P]ATP into myelin basic protein after 30 mins by scintillatio...


J Med Chem 54: 2255-65 (2011)


Article DOI: 10.1021/jm101423y
BindingDB Entry DOI: 10.7270/Q20P109X
More data for this
Ligand-Target Pair