BDBM50341469 8-Isoquinolin-4-yl-1,2,5,6-tetrahydro-4H-pyrrolo[3,2,1-ij]quinolin-4-one::CHEMBL1765214

SMILES: O=C1CCc2cc(cc3CCN1c23)-c1cncc2ccccc12

InChI Key: InChIKey=AREOIQPVPKMWCA-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50341469   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Cytochrome P450 11B2 (CYP11B2) (Homo sapiens (Human))	BDBM50341469 (8-Isoquinolin-4-yl-1,2,5,6-tetrahydro-4H-pyrrolo[3...) Show SMILES O=C1CCc2cc(cc3CCN1c23)-c1cncc2ccccc12 Show InChI InChI=1S/C20H16N2O/c23-19-6-5-13-9-16(10-14-7-8-22(19)20(13)14)18-12-21-11-15-3-1-2-4-17(15)18/h1-4,9-12H,5-8H2	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	0.200	n/a	n/a	n/a	n/a	n/a	n/a
Saarland University Curated by ChEMBL					Assay Description Inhibition of human CYP11B2 expressed in hamster V79 MZh cells assessed as conversion of [4-14C]-11-deoxycorticosterone substrate by HPTLC assay				J Med Chem 54: 2307-19 (2011) Article DOI: 10.1021/jm101470k BindingDB Entry DOI: 10.7270/Q2765FM6
					More data for this Ligand-Target Pair
Cytochrome P450 11B1, mitochondrial (Homo sapiens (Human))	BDBM50341469 (8-Isoquinolin-4-yl-1,2,5,6-tetrahydro-4H-pyrrolo[3...) Show SMILES O=C1CCc2cc(cc3CCN1c23)-c1cncc2ccccc12 Show InChI InChI=1S/C20H16N2O/c23-19-6-5-13-9-16(10-14-7-8-22(19)20(13)14)18-12-21-11-15-3-1-2-4-17(15)18/h1-4,9-12H,5-8H2	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	13	n/a	n/a	n/a	n/a	n/a	n/a
Saarland University Curated by ChEMBL					Assay Description Inhibition of human CYP11B1 expressed in hamster V79 MZh cells assessed as conversion of [4-14C]-11-deoxycorticosterone substrate by HPTLC assay				J Med Chem 54: 2307-19 (2011) Article DOI: 10.1021/jm101470k BindingDB Entry DOI: 10.7270/Q2765FM6
					More data for this Ligand-Target Pair