BDBM50341570 7-Chloro-3-(3,5-dimethylphenyl)-4-{2-[(2R)-piperidin-2-yl]ethoxy}-6-(pyridin-4-yl)quinoline::CHEMBL1766095
SMILES: Cc1cc(C)cc(c1)-c1cnc2cc(Cl)c(cc2c1OCC[C@H]1CCCCN1)-c1ccncc1
InChI Key: InChIKey=KXIDRPHEXRTZHO-HSZRJFAPSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Somatostatin receptor type 2 (Homo sapiens (Human)) | BDBM50341570 (7-Chloro-3-(3,5-dimethylphenyl)-4-{2-[(2R)-piperid...) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 0.110 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories Curated by ChEMBL | Assay Description Displacement of I125-somatostatin-14 from human SST2 expressed in CHO cells after 3 hrs by scintillation counting | J Med Chem 54: 2351-8 (2011) Article DOI: 10.1021/jm101501b BindingDB Entry DOI: 10.7270/Q2668DH8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Somatostatin receptor type 2 (Homo sapiens (Human)) | BDBM50341570 (7-Chloro-3-(3,5-dimethylphenyl)-4-{2-[(2R)-piperid...) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories Curated by ChEMBL | Assay Description Agonist activity at human SST2 expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP release after 40 mins by luminescence assay | J Med Chem 54: 2351-8 (2011) Article DOI: 10.1021/jm101501b BindingDB Entry DOI: 10.7270/Q2668DH8 | |||||||||||
More data for this Ligand-Target Pair |