BindingDB PrimarySearch

BDBM50342601 CHEMBL1255901::Huperzine A

SMILES: C\C=C1/[C@@H]2Cc3[nH]c(=O)ccc3[C@]1(N)CC(C)=C2

InChI Key: InChIKey=ZRJBHWIHUMBLCN-HZRLMBICSA-N

Data: 6 KI 17 IC50 2 K_off 3 K_on

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 27 hits for monomerid = 50342601
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Acetylcholinesterase (Bos taurus (bovine))	BDBM50342601 (CHEMBL1255901 \| Huperzine A) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article	5.90	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Dissociation constant for the inhibition of fetal bovine serum acetylcholinesterase was determined..				Bioorg Med Chem Lett 6: 259-262 (1996) Article DOI: 10.1016/0960-894X(96)00012-1 BindingDB Entry DOI: 10.7270/Q2R49R8X
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Acetylcholinesterase (Bos taurus (bovine))	BDBM50342601 (CHEMBL1255901 \| Huperzine A) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	PubMed	5.90	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Georgetown University Medical Center Curated by ChEMBL					Assay Description Binding affinity towards Acetylcholinesterase from fetal bovine serum				Bioorg Med Chem Lett 10: 2467-9 (2001) BindingDB Entry DOI: 10.7270/Q2R211X1
Georgetown University Medical Center Curated by ChEMBL					More data for this Ligand-Target Pair
Acetylcholinesterase (Bos taurus (bovine))	BDBM50342601 (CHEMBL1255901 \| Huperzine A) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	PubMed	24	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Georgetown University Medical Center Curated by ChEMBL					Assay Description Inhibitory constant against fetal bovine serum (FBS) acetylcholinesterase				Bioorg Med Chem Lett 12: 1521-3 (2002) BindingDB Entry DOI: 10.7270/Q2FX79ZW
Georgetown University Medical Center Curated by ChEMBL					More data for this Ligand-Target Pair
Acetylcholinesterase (Bos taurus (bovine))	BDBM50342601 (CHEMBL1255901 \| Huperzine A) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article	24	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Dissociation constant for the inhibition of fetal bovine serum acetylcholinesterase was determined..				Bioorg Med Chem Lett 6: 259-262 (1996) Article DOI: 10.1016/0960-894X(96)00012-1 BindingDB Entry DOI: 10.7270/Q2R49R8X
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Acetylcholinesterase (Rattus norvegicus (rat))	BDBM50342601 (CHEMBL1255901 \| Huperzine A) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	PubMed	24	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universit£t Wien Curated by ChEMBL					Assay Description Compound was tested for its ability to inhibit acetylcholinesterase (AChE) in rat brain; 0.024-0.040 uM				Bioorg Med Chem Lett 11: 2627-30 (2001) BindingDB Entry DOI: 10.7270/Q2VH5PCN
Universit£t Wien Curated by ChEMBL					More data for this Ligand-Target Pair
Acetylcholinesterase (Tetronarce californica (Pacific electric ray) (Tor...)	BDBM50342601 (CHEMBL1255901 \| Huperzine A) Show SMILES Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	175	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ di Siena Curated by ChEMBL					Assay Description Inhibition of Torpedo californica AChE				J Med Chem 51: 3154-70 (2008) Article DOI: 10.1021/jm701253t BindingDB Entry DOI: 10.7270/Q22Z16D4
Universit£ di Siena Curated by ChEMBL					More data for this Ligand-Target Pair
Acetylcholinesterase (Rattus norvegicus (rat))	BDBM50342601 (CHEMBL1255901 \| Huperzine A) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	45	n/a	n/a	n/a	n/a	n/a	n/a
Mayo Clinic Jacksonville Curated by ChEMBL					Assay Description Compound was tested for its ability to inhibit the action of acetylcholinesterase isolated from rat brain cortex				J Med Chem 34: 3399-402 (1992) BindingDB Entry DOI: 10.7270/Q2TB17HH
Mayo Clinic Jacksonville Curated by ChEMBL					More data for this Ligand-Target Pair
Carboxylic ester hydrolase (Rattus norvegicus (rat))	BDBM50342601 (CHEMBL1255901 \| Huperzine A) Show SMILES Show InChI	Reactome pathway KEGG UniProtKB/TrEMBL GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	>1.00E+6	n/a	n/a	n/a	n/a	n/a	n/a
Hoechst-Roussel Pharmaceuticals, Inc Curated by ChEMBL					Assay Description The compound was tested for Butyrylcholinesterase inhibitory activity in rat striatal homogenates				J Med Chem 38: 3645-51 (1995) BindingDB Entry DOI: 10.7270/Q2X34Z3G
Hoechst-Roussel Pharmaceuticals, Inc Curated by ChEMBL					More data for this Ligand-Target Pair
Acetylcholinesterase (Rattus norvegicus (rat))	BDBM50342601 (CHEMBL1255901 \| Huperzine A) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	80	n/a	n/a	n/a	n/a	n/a	n/a
Hoechst-Roussel Pharmaceuticals, Inc Curated by ChEMBL					Assay Description Acetylcholinesterase inhibitory activity in rat striatal homogenates				J Med Chem 38: 3645-51 (1995) BindingDB Entry DOI: 10.7270/Q2X34Z3G
Hoechst-Roussel Pharmaceuticals, Inc Curated by ChEMBL					More data for this Ligand-Target Pair
Acetylcholinesterase (Rattus norvegicus (rat))	BDBM50342601 (CHEMBL1255901 \| Huperzine A) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	114	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ di Siena Curated by ChEMBL					Assay Description Inhibition of rat AChE				J Med Chem 51: 3154-70 (2008) Article DOI: 10.1021/jm701253t BindingDB Entry DOI: 10.7270/Q22Z16D4
Universit£ di Siena Curated by ChEMBL					More data for this Ligand-Target Pair
Acetylcholinesterase (Homo sapiens (Human))	BDBM50342601 (CHEMBL1255901 \| Huperzine A) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.540	n/a	n/a	n/a	n/a	n/a	n/a
Zhejiang University Curated by ChEMBL					Assay Description Inhibition of acetylcholinesterase (unknown origin) assessed as inhibition of acetylcholine hydrolysis after 30 mins by Ellmann's method				J Nat Prod 77: 2054-9 (2014) Article DOI: 10.1021/np500412f BindingDB Entry DOI: 10.7270/Q2BC4147
Zhejiang University Curated by ChEMBL					More data for this Ligand-Target Pair
Acetylcholinesterase (Homo sapiens (Human))	BDBM50342601 (CHEMBL1255901 \| Huperzine A) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
Alchemical Research, LLC Curated by ChEMBL					Assay Description Inhibition of AChE (unknown origin)				Bioorg Med Chem Lett 25: 4848-53 (2015) BindingDB Entry DOI: 10.7270/Q2668G1T
Alchemical Research, LLC Curated by ChEMBL					More data for this Ligand-Target Pair
Acetylcholinesterase (Homo sapiens (Human))	BDBM50342601 (CHEMBL1255901 \| Huperzine A) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
Alchemical Research, LLC Curated by ChEMBL					Assay Description Inhibition of AChE-induced amyloid beta aggregation				Bioorg Med Chem Lett 21: 2687-91 (2011) Article DOI: 10.1016/j.bmcl.2010.12.041 BindingDB Entry DOI: 10.7270/Q27W6CH9
Alchemical Research, LLC Curated by ChEMBL					More data for this Ligand-Target Pair
Cholinesterases (Homo sapiens (Human))	BDBM50342601 (CHEMBL1255901 \| Huperzine A) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	100	n/a	n/a	n/a	n/a	n/a	n/a
Alchemical Research, LLC Curated by ChEMBL					Assay Description Inhibition of BChE				Bioorg Med Chem Lett 21: 2687-91 (2011) Article DOI: 10.1016/j.bmcl.2010.12.041 BindingDB Entry DOI: 10.7270/Q27W6CH9
Alchemical Research, LLC Curated by ChEMBL					More data for this Ligand-Target Pair
Acetylcholinesterase (Rattus norvegicus (rat))	BDBM50342601 (CHEMBL1255901 \| Huperzine A) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	80	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description In vitro inhibitory activity against Acetylcholinesterase (AChE) using rat brain hippocampal crude homogenates.				Bioorg Med Chem Lett 8: 1661-4 (1999) BindingDB Entry DOI: 10.7270/Q2319WC0
Chinese Academy of Sciences Curated by ChEMBL					More data for this Ligand-Target Pair
Acetylcholinesterase (Mus musculus (mouse))	BDBM50342601 (CHEMBL1255901 \| Huperzine A) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	82	n/a	n/a	n/a	n/a	n/a	n/a
Ume£ University Curated by ChEMBL					Assay Description Inhibition of mouse AChE				J Med Chem 56: 7615-24 (2013) Article DOI: 10.1021/jm400990p BindingDB Entry DOI: 10.7270/Q24M95Z3
Ume£ University Curated by ChEMBL					More data for this Ligand-Target Pair
Acetylcholinesterase (Bos taurus (bovine))	BDBM50342601 (CHEMBL1255901 \| Huperzine A) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article	n/a	n/a	n/a	n/a	n/a	0.000333	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Dissociation constant for the inhibition of fetal bovine serum acetylcholinesterase was determined..				Bioorg Med Chem Lett 6: 259-262 (1996) Article DOI: 10.1016/0960-894X(96)00012-1 BindingDB Entry DOI: 10.7270/Q2R49R8X
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Acetylcholinesterase (Bos taurus (bovine))	BDBM50342601 (CHEMBL1255901 \| Huperzine A) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article	n/a	n/a	n/a	n/a	n/a	n/a	0.0155	n/a	n/a
TBA Curated by ChEMBL					Assay Description Kinetic constant for inhibition of fetal bovine serum acetylcholinesterase				Bioorg Med Chem Lett 6: 259-262 (1996) Article DOI: 10.1016/0960-894X(96)00012-1 BindingDB Entry DOI: 10.7270/Q2R49R8X
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Acetylcholinesterase (Bos taurus (bovine))	BDBM50342601 (CHEMBL1255901 \| Huperzine A) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article	n/a	n/a	n/a	n/a	n/a	n/a	0.0567	n/a	n/a
TBA Curated by ChEMBL					Assay Description Kinetic constant for inhibition of fetal bovine serum acetylcholinesterase				Bioorg Med Chem Lett 6: 259-262 (1996) Article DOI: 10.1016/0960-894X(96)00012-1 BindingDB Entry DOI: 10.7270/Q2R49R8X
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Acetylcholinesterase (Homo sapiens (Human))	BDBM50342601 (CHEMBL1255901 \| Huperzine A) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	12	n/a	n/a	n/a	n/a	n/a	n/a
Kieler Wirkstoff-Zentrum (KiWiZ) at the Helmholtz-Zenrum f�r Ozeanforschung GEOMAR Curated by ChEMBL					Assay Description Inhibition of human AChE pre-incubated for 10 mins before acetylthiocholine iodide substrate addition				J Nat Prod 75: 1400-4 (2012) Article DOI: 10.1021/np2009626 BindingDB Entry DOI: 10.7270/Q2M61MBK
					More data for this Ligand-Target Pair
Acetylcholinesterase (Rattus norvegicus (rat))	BDBM50342601 (CHEMBL1255901 \| Huperzine A) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article	n/a	n/a	94	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibitory activity against acetylcholinesterase in rat brain				Bioorg Med Chem Lett 6: 737-742 (1996) Article DOI: 10.1016/0960-894X(96)00102-3 BindingDB Entry DOI: 10.7270/Q2736RDK
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Acetylcholinesterase (Homo sapiens (Human))	BDBM50342601 (CHEMBL1255901 \| Huperzine A) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article	n/a	n/a	150	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibitory activity against acetylcholinesterase in human RBC				Bioorg Med Chem Lett 6: 737-742 (1996) Article DOI: 10.1016/0960-894X(96)00102-3 BindingDB Entry DOI: 10.7270/Q2736RDK
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Acetylcholinesterase (Bos taurus (bovine))	BDBM50342601 (CHEMBL1255901 \| Huperzine A) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article	n/a	n/a	n/a	n/a	n/a	0.000367	0.0155	n/a	n/a
TBA Curated by ChEMBL					Assay Description Dissociation constant for the inhibition of fetal bovine serum acetylcholinesterase was determined..				Bioorg Med Chem Lett 6: 259-262 (1996) Article DOI: 10.1016/0960-894X(96)00012-1 BindingDB Entry DOI: 10.7270/Q2R49R8X
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Acetylcholinesterase (Homo sapiens (Human))	BDBM50342601 (CHEMBL1255901 \| Huperzine A) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description In vitro inhibitory activity against Acetylcholinesterase (AChE).				Bioorg Med Chem Lett 6: 1927-1930 (1996) Article DOI: 10.1016/0960-894X(96)00337-X BindingDB Entry DOI: 10.7270/Q2P84CD1
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Acetylcholinesterase (Rattus norvegicus (rat))	BDBM50342601 (CHEMBL1255901 \| Huperzine A) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	72	n/a	n/a	n/a	n/a	n/a	n/a
Mayo Clinic Jacksonville Curated by ChEMBL					Assay Description Compound was tested for its ability to inhibit the action of acetylcholinesterase isolated from rat brain cortex				J Med Chem 34: 3399-402 (1992) BindingDB Entry DOI: 10.7270/Q2TB17HH
Mayo Clinic Jacksonville Curated by ChEMBL					More data for this Ligand-Target Pair
Acetylcholinesterase (Rattus norvegicus (rat))	BDBM50342601 (CHEMBL1255901 \| Huperzine A) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	114	n/a	n/a	n/a	n/a	n/a	n/a
Hong Kong University of Science and Technology Curated by ChEMBL					Assay Description Inhibitory potency against acetylcholinesterase (AChE) of rat cortex homogenate with ethopropazine as BChE inhibitor				Bioorg Med Chem Lett 9: 2335-8 (1999) BindingDB Entry DOI: 10.7270/Q2PK0GPF
					More data for this Ligand-Target Pair
Carboxylic ester hydrolase (Rattus norvegicus (rat))	BDBM50342601 (CHEMBL1255901 \| Huperzine A) Show SMILES Show InChI	Reactome pathway KEGG UniProtKB/TrEMBL GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	1.35E+5	n/a	n/a	n/a	n/a	n/a	n/a
Hong Kong University of Science and Technology Curated by ChEMBL					Assay Description Inhibitory potency against rat serum Butyrylcholinesterase with BW284c51 as AChE inhibitor				Bioorg Med Chem Lett 9: 2335-8 (1999) BindingDB Entry DOI: 10.7270/Q2PK0GPF
					More data for this Ligand-Target Pair