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BDBM50342743 (R)-2-(2-phenoxyphenylsulfonamido)-3-(3,7,11-trimethyldodeca-2,6,10-trienylthio)propanoic acid::CHEMBL1771313

SMILES: [#6]\[#6](-[#6])=[#6]\[#6]-[#6]\[#6](-[#6])=[#6]\[#6]-[#6]\[#6](-[#6])=[#6]\[#6]-[#16]-[#6]-[#6@H](-[#7]S(=O)(=O)c1ccccc1-[#8]-c1ccccc1)-[#6](-[#8])=O

InChI Key: InChIKey=LFZYDNHNQFRHDP-FDVXRVMTSA-N

Data: 1 IC50

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   Substructure
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50342743   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Isoprenylcysteine carboxyl methyltransferase


(Homo sapiens (Human))
BDBM50342743
PNG
((R)-2-(2-phenoxyphenylsulfonamido)-3-(3,7,11-trime...)
Show SMILES [#6]\[#6](-[#6])=[#6]\[#6]-[#6]\[#6](-[#6])=[#6]\[#6]-[#6]\[#6](-[#6])=[#6]\[#6]-[#16]-[#6]-[#6@H](-[#7]S(=O)(=O)c1ccccc1-[#8]-c1ccccc1)-[#6](-[#8])=O |r|
Show InChI InChI=1S/C30H39NO5S2/c1-23(2)12-10-13-24(3)14-11-15-25(4)20-21-37-22-27(30(32)33)31-38(34,35)29-19-9-8-18-28(29)36-26-16-6-5-7-17-26/h5-9,12,14,16-20,27,31H,10-11,13,15,21-22H2,1-4H3,(H,32,33)/b24-14+,25-20+/t27-/m0/s1
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 1.84E+4n/an/an/an/an/an/a



Purdue University

Curated by ChEMBL


Assay Description
Inhibition of human ICMT incubated with N-Acetyl-S-farnesyl-L-cysteine substrate for 5 mins followed by addition of [14C]-SAM measured after 30 mins ...


Bioorg Med Chem Lett 21: 2616-20 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.078
BindingDB Entry DOI: 10.7270/Q2348KNH
More data for this
Ligand-Target Pair