BDBM50342887 (1S,2S,3S,4R,5S)-5-[4-Chloro-3-(4-methoxybenzyl)phenyl]-1-(hydroxymethyl)-6,8-dioxa-bicyclo[3.2.1]octane-2,3,4-triol::CHEMBL1770246
SMILES: COc1ccc(Cc2cc(ccc2Cl)[C@]23OC[C@](CO)(O2)[C@@H](O)[C@H](O)[C@H]3O)cc1
InChI Key: InChIKey=RJTVHYMNUOKZQZ-WHZJULEDSA-N
Data: 2 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Low affinity sodium-glucose cotransporter (Homo sapiens (Human)) | BDBM50342887 ((1S,2S,3S,4R,5S)-5-[4-Chloro-3-(4-methoxybenzyl)ph...) | Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 0.882 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc. Curated by ChEMBL | Assay Description Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of methyl alpha-D-glucopyranoside uptake after 1 hr | J Med Chem 54: 2952-60 (2011) Article DOI: 10.1021/jm200049r BindingDB Entry DOI: 10.7270/Q2NZ880H | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium/glucose cotransporter 1 (SGLT1) (Homo sapiens (Human)) | BDBM50342887 ((1S,2S,3S,4R,5S)-5-[4-Chloro-3-(4-methoxybenzyl)ph...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 546 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc. Curated by ChEMBL | Assay Description Inhibition of human SGLT1 expressed in CHO cells assessed as inhibition of methyl alpha-D-glucopyranoside uptake after 1 hr | J Med Chem 54: 2952-60 (2011) Article DOI: 10.1021/jm200049r BindingDB Entry DOI: 10.7270/Q2NZ880H | |||||||||||
More data for this Ligand-Target Pair |