Found 4 hits for monomerid = 50343060 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Matrix metalloproteinase-9
(Homo sapiens (Human)) | BDBM50343060
(4-(4-(4-(4-(dimethylamino)phenylamino)-4-oxobutoxy...)Show SMILES CN(C)c1ccc(NC(=O)CCCOc2ccc(cc2)S(=O)(=O)C2(CCOCC2)C(=O)NO)cc1 Show InChI InChI=1S/C24H31N3O7S/c1-27(2)19-7-5-18(6-8-19)25-22(28)4-3-15-34-20-9-11-21(12-10-20)35(31,32)24(23(29)26-30)13-16-33-17-14-24/h5-12,30H,3-4,13-17H2,1-2H3,(H,25,28)(H,26,29) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 960 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description Inhibition of human MMP9 |
Bioorg Med Chem Lett 21: 2823-5 (2011)
Article DOI: 10.1016/j.bmcl.2011.03.095 BindingDB Entry DOI: 10.7270/Q2CF9QD0 |
More data for this Ligand-Target Pair | |
Collagenase 3
(Homo sapiens (Human)) | BDBM50343060
(4-(4-(4-(4-(dimethylamino)phenylamino)-4-oxobutoxy...)Show SMILES CN(C)c1ccc(NC(=O)CCCOc2ccc(cc2)S(=O)(=O)C2(CCOCC2)C(=O)NO)cc1 Show InChI InChI=1S/C24H31N3O7S/c1-27(2)19-7-5-18(6-8-19)25-22(28)4-3-15-34-20-9-11-21(12-10-20)35(31,32)24(23(29)26-30)13-16-33-17-14-24/h5-12,30H,3-4,13-17H2,1-2H3,(H,25,28)(H,26,29) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 1.70 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description Inhibition of human MMP13 |
Bioorg Med Chem Lett 21: 2823-5 (2011)
Article DOI: 10.1016/j.bmcl.2011.03.095 BindingDB Entry DOI: 10.7270/Q2CF9QD0 |
More data for this Ligand-Target Pair | |
Neutrophil collagenase
(Homo sapiens (Human)) | BDBM50343060
(4-(4-(4-(4-(dimethylamino)phenylamino)-4-oxobutoxy...)Show SMILES CN(C)c1ccc(NC(=O)CCCOc2ccc(cc2)S(=O)(=O)C2(CCOCC2)C(=O)NO)cc1 Show InChI InChI=1S/C24H31N3O7S/c1-27(2)19-7-5-18(6-8-19)25-22(28)4-3-15-34-20-9-11-21(12-10-20)35(31,32)24(23(29)26-30)13-16-33-17-14-24/h5-12,30H,3-4,13-17H2,1-2H3,(H,25,28)(H,26,29) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 100 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description Inhibition of human MMP8 |
Bioorg Med Chem Lett 21: 2823-5 (2011)
Article DOI: 10.1016/j.bmcl.2011.03.095 BindingDB Entry DOI: 10.7270/Q2CF9QD0 |
More data for this Ligand-Target Pair | |
72 kDa type IV collagenase
(Homo sapiens (Human)) | BDBM50343060
(4-(4-(4-(4-(dimethylamino)phenylamino)-4-oxobutoxy...)Show SMILES CN(C)c1ccc(NC(=O)CCCOc2ccc(cc2)S(=O)(=O)C2(CCOCC2)C(=O)NO)cc1 Show InChI InChI=1S/C24H31N3O7S/c1-27(2)19-7-5-18(6-8-19)25-22(28)4-3-15-34-20-9-11-21(12-10-20)35(31,32)24(23(29)26-30)13-16-33-17-14-24/h5-12,30H,3-4,13-17H2,1-2H3,(H,25,28)(H,26,29) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description Inhibition of human MMP2 |
Bioorg Med Chem Lett 21: 2823-5 (2011)
Article DOI: 10.1016/j.bmcl.2011.03.095 BindingDB Entry DOI: 10.7270/Q2CF9QD0 |
More data for this Ligand-Target Pair | |