Found 3 hits for monomerid = 50343194 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM50343194
(CHEMBL1773581 | N-(6-(2-(4-Methylphenylsulfonamido...)Show SMILES CC(=O)Nc1nc2ccc(cc2s1)-c1ccnc(NS(=O)(=O)c2ccc(C)cc2)n1 Show InChI InChI=1S/C20H17N5O3S2/c1-12-3-6-15(7-4-12)30(27,28)25-19-21-10-9-16(23-19)14-5-8-17-18(11-14)29-20(24-17)22-13(2)26/h3-11H,1-2H3,(H,21,23,25)(H,22,24,26) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| 82 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description Inhibition of human PI3Kalpha expressed in Sf9 cells |
J Med Chem 54: 1789-811 (2011)
Article DOI: 10.1021/jm1014605 BindingDB Entry DOI: 10.7270/Q2TH8N1K |
More data for this Ligand-Target Pair | |
Serine/threonine-protein kinase mTOR
(Homo sapiens (Human)) | BDBM50343194
(CHEMBL1773581 | N-(6-(2-(4-Methylphenylsulfonamido...)Show SMILES CC(=O)Nc1nc2ccc(cc2s1)-c1ccnc(NS(=O)(=O)c2ccc(C)cc2)n1 Show InChI InChI=1S/C20H17N5O3S2/c1-12-3-6-15(7-4-12)30(27,28)25-19-21-10-9-16(23-19)14-5-8-17-18(11-14)29-20(24-17)22-13(2)26/h3-11H,1-2H3,(H,21,23,25)(H,22,24,26) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 65 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description Inhibition of mTOR assessed as inhibition of 4EBP1 phosphorylation by TR-FRET assay |
J Med Chem 54: 1789-811 (2011)
Article DOI: 10.1021/jm1014605 BindingDB Entry DOI: 10.7270/Q2TH8N1K |
More data for this Ligand-Target Pair | |
RAC-alpha serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM50343194
(CHEMBL1773581 | N-(6-(2-(4-Methylphenylsulfonamido...)Show SMILES CC(=O)Nc1nc2ccc(cc2s1)-c1ccnc(NS(=O)(=O)c2ccc(C)cc2)n1 Show InChI InChI=1S/C20H17N5O3S2/c1-12-3-6-15(7-4-12)30(27,28)25-19-21-10-9-16(23-19)14-5-8-17-18(11-14)29-20(24-17)22-13(2)26/h3-11H,1-2H3,(H,21,23,25)(H,22,24,26) | PDB
UniProtKB/SwissProt UniProtKB/TrEMBL
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 1.26E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description Inhibition of AKT phosphorylation at S473 in human U-87MG cells at 5 mM after 2 hrs |
J Med Chem 54: 1789-811 (2011)
Article DOI: 10.1021/jm1014605 BindingDB Entry DOI: 10.7270/Q2TH8N1K |
More data for this Ligand-Target Pair | |