BDBM50343221 CHEMBL1773588::N-(6-(2-(Benzylamino)pyrimidin-4-yl)benzo[d]thiazol-2-yl)acetamide

SMILES: CC(=O)Nc1nc2ccc(cc2s1)-c1ccnc(NCc2ccccc2)n1

InChI Key: InChIKey=ZKBNFXQBWVGNHF-UHFFFAOYSA-N

Data: 1 KI  2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50343221   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM50343221 (CHEMBL1773588 | N-(6-(2-(Benzylamino)pyrimidin-4-y...) Show SMILES CC(=O)Nc1nc2ccc(cc2s1)-c1ccnc(NCc2ccccc2)n1 Show InChI InChI=1S/C20H17N5OS/c1-13(26)23-20-25-17-8-7-15(11-18(17)27-20)16-9-10-21-19(24-16)22-12-14-5-3-2-4-6-14/h2-11H,12H2,1H3,(H,21,22,24)(H,23,25,26)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	85	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of human PI3Kalpha expressed in Sf9 cells				J Med Chem 54: 1789-811 (2011) Article DOI: 10.1021/jm1014605 BindingDB Entry DOI: 10.7270/Q2TH8N1K
					More data for this Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human))	BDBM50343221 (CHEMBL1773588 | N-(6-(2-(Benzylamino)pyrimidin-4-y...) Show SMILES CC(=O)Nc1nc2ccc(cc2s1)-c1ccnc(NCc2ccccc2)n1 Show InChI InChI=1S/C20H17N5OS/c1-13(26)23-20-25-17-8-7-15(11-18(17)27-20)16-9-10-21-19(24-16)22-12-14-5-3-2-4-6-14/h2-11H,12H2,1H3,(H,21,22,24)(H,23,25,26)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>5.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of AKT phosphorylation at S473 in human U-87MG cells at 5 mM after 2 hrs				J Med Chem 54: 1789-811 (2011) Article DOI: 10.1021/jm1014605 BindingDB Entry DOI: 10.7270/Q2TH8N1K
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase mTOR (Homo sapiens (Human))	BDBM50343221 (CHEMBL1773588 | N-(6-(2-(Benzylamino)pyrimidin-4-y...) Show SMILES CC(=O)Nc1nc2ccc(cc2s1)-c1ccnc(NCc2ccccc2)n1 Show InChI InChI=1S/C20H17N5OS/c1-13(26)23-20-25-17-8-7-15(11-18(17)27-20)16-9-10-21-19(24-16)22-12-14-5-3-2-4-6-14/h2-11H,12H2,1H3,(H,21,22,24)(H,23,25,26)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>6.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of mTOR assessed as inhibition of 4EBP1 phosphorylation by TR-FRET assay				J Med Chem 54: 1789-811 (2011) Article DOI: 10.1021/jm1014605 BindingDB Entry DOI: 10.7270/Q2TH8N1K
					More data for this Ligand-Target Pair