BDBM50343246 CHEMBL1773572::N-(6-(2-(2-Phenylpropan-2-ylamino)pyrimidin-4-yl)benzo[d]thiazol-2-yl)acetamide

SMILES: CC(=O)Nc1nc2ccc(cc2s1)-c1ccnc(NC(C)(C)c2ccccc2)n1

InChI Key: InChIKey=YWWPYGURSDURBZ-UHFFFAOYSA-N

Data: 1 KI  2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50343246   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM50343246 (CHEMBL1773572 | N-(6-(2-(2-Phenylpropan-2-ylamino)...) Show SMILES CC(=O)Nc1nc2ccc(cc2s1)-c1ccnc(NC(C)(C)c2ccccc2)n1 Show InChI InChI=1S/C22H21N5OS/c1-14(28)24-21-26-18-10-9-15(13-19(18)29-21)17-11-12-23-20(25-17)27-22(2,3)16-7-5-4-6-8-16/h4-13H,1-3H3,(H,23,25,27)(H,24,26,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	24	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of human PI3Kalpha expressed in Sf9 cells				J Med Chem 54: 1789-811 (2011) Article DOI: 10.1021/jm1014605 BindingDB Entry DOI: 10.7270/Q2TH8N1K
					More data for this Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human))	BDBM50343246 (CHEMBL1773572 | N-(6-(2-(2-Phenylpropan-2-ylamino)...) Show SMILES CC(=O)Nc1nc2ccc(cc2s1)-c1ccnc(NC(C)(C)c2ccccc2)n1 Show InChI InChI=1S/C22H21N5OS/c1-14(28)24-21-26-18-10-9-15(13-19(18)29-21)17-11-12-23-20(25-17)27-22(2,3)16-7-5-4-6-8-16/h4-13H,1-3H3,(H,23,25,27)(H,24,26,28)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	2.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of AKT phosphorylation at S473 in human U-87MG cells at 5 mM after 2 hrs				J Med Chem 54: 1789-811 (2011) Article DOI: 10.1021/jm1014605 BindingDB Entry DOI: 10.7270/Q2TH8N1K
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase mTOR (Homo sapiens (Human))	BDBM50343246 (CHEMBL1773572 | N-(6-(2-(2-Phenylpropan-2-ylamino)...) Show SMILES CC(=O)Nc1nc2ccc(cc2s1)-c1ccnc(NC(C)(C)c2ccccc2)n1 Show InChI InChI=1S/C22H21N5OS/c1-14(28)24-21-26-18-10-9-15(13-19(18)29-21)17-11-12-23-20(25-17)27-22(2,3)16-7-5-4-6-8-16/h4-13H,1-3H3,(H,23,25,27)(H,24,26,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>6.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of mTOR assessed as inhibition of 4EBP1 phosphorylation by TR-FRET assay				J Med Chem 54: 1789-811 (2011) Article DOI: 10.1021/jm1014605 BindingDB Entry DOI: 10.7270/Q2TH8N1K
					More data for this Ligand-Target Pair