null
SMILES: Cn1c(CN2CCC(CC2)c2ccccc2F)nc2ccccc12
InChI Key: InChIKey=AMADNKXMEDYTCS-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
D(2) dopamine receptor (Homo sapiens (Human)) | BDBM50343299 (2-((4-(2-Fluorophenyl)piperidin-1-yl)methyl)-1-met...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 39.8 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Curated by ChEMBL | Assay Description Antagonist activity at human D2 receptor expressed in CHO cells co-expressing G0 by [35S]GTPgammaS binding assay | Bioorg Med Chem Lett 20: 759-62 (2010) Article DOI: 10.1016/j.bmcl.2009.11.032 BindingDB Entry DOI: 10.7270/Q2CC11XQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D(2) dopamine receptor (Rattus norvegicus (rat)) | BDBM50343299 (2-((4-(2-Fluorophenyl)piperidin-1-yl)methyl)-1-met...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 93 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc. Curated by ChEMBL | Assay Description Displacement of [3H]spiperone from dopamine D2 receptor in rat corpus striatum by beta plate scintillation counting | J Med Chem 54: 1724-39 (2011) Article DOI: 10.1021/jm101414h BindingDB Entry DOI: 10.7270/Q2222V3C | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D(3) dopamine receptor (Homo sapiens (Human)) | BDBM50343299 (2-((4-(2-Fluorophenyl)piperidin-1-yl)methyl)-1-met...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 100 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Curated by ChEMBL | Assay Description Antagonist activity at human D3 receptor expressed in CHO cells co-expressing G0 by [35S]GTPgammaS binding assay | Bioorg Med Chem Lett 20: 759-62 (2010) Article DOI: 10.1016/j.bmcl.2009.11.032 BindingDB Entry DOI: 10.7270/Q2CC11XQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 5 (Homo sapiens (Human)) | BDBM50343299 (2-((4-(2-Fluorophenyl)piperidin-1-yl)methyl)-1-met...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | >1.58E+4 | n/a | n/a | n/a | n/a |
GlaxoSmithKline Curated by ChEMBL | Assay Description Agonist activity at mGluR5 | Bioorg Med Chem Lett 20: 759-62 (2010) Article DOI: 10.1016/j.bmcl.2009.11.032 BindingDB Entry DOI: 10.7270/Q2CC11XQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 2 (Homo sapiens (Human)) | BDBM50343299 (2-((4-(2-Fluorophenyl)piperidin-1-yl)methyl)-1-met...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | n/a | n/a | n/a | n/a | 130 | n/a | n/a | n/a | n/a | |
TBA | Citation and Details | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 5 (Homo sapiens (Human)) | BDBM50343299 (2-((4-(2-Fluorophenyl)piperidin-1-yl)methyl)-1-met...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | >1.58E+4 | n/a | n/a | n/a | n/a |
GlaxoSmithKline Curated by ChEMBL | Assay Description Positive modulation of mGluR5 | Bioorg Med Chem Lett 20: 759-62 (2010) Article DOI: 10.1016/j.bmcl.2009.11.032 BindingDB Entry DOI: 10.7270/Q2CC11XQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 2 (Homo sapiens (Human)) | BDBM50343299 (2-((4-(2-Fluorophenyl)piperidin-1-yl)methyl)-1-met...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 126 | n/a | n/a | n/a | n/a |
GlaxoSmithKline Curated by ChEMBL | Assay Description Positive modulation of human mGluR2 expressed in CHO cells co-expressing Ga16 G-protein assessed as glutamate-induced response by FLIPR assay | Bioorg Med Chem Lett 20: 759-62 (2010) Article DOI: 10.1016/j.bmcl.2009.11.032 BindingDB Entry DOI: 10.7270/Q2CC11XQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 2 (Homo sapiens (Human)) | BDBM50343299 (2-((4-(2-Fluorophenyl)piperidin-1-yl)methyl)-1-met...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 3.98E+3 | n/a | n/a | n/a | n/a |
GlaxoSmithKline Curated by ChEMBL | Assay Description Agonist activity at human mGluR2 expressed in CHO cells co-expressing Ga16 G-protein assessed as glutamate-induced response by FLIPR assay | Bioorg Med Chem Lett 20: 759-62 (2010) Article DOI: 10.1016/j.bmcl.2009.11.032 BindingDB Entry DOI: 10.7270/Q2CC11XQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 1 (Homo sapiens (Human)) | BDBM50343299 (2-((4-(2-Fluorophenyl)piperidin-1-yl)methyl)-1-met...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | >1.58E+4 | n/a | n/a | n/a | n/a |
GlaxoSmithKline Curated by ChEMBL | Assay Description Antagonist activity at mGluR1 | Bioorg Med Chem Lett 20: 759-62 (2010) Article DOI: 10.1016/j.bmcl.2009.11.032 BindingDB Entry DOI: 10.7270/Q2CC11XQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 1 (Homo sapiens (Human)) | BDBM50343299 (2-((4-(2-Fluorophenyl)piperidin-1-yl)methyl)-1-met...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | >1.58E+4 | n/a | n/a | n/a | n/a |
GlaxoSmithKline Curated by ChEMBL | Assay Description Agonist activity at mGluR1 | Bioorg Med Chem Lett 20: 759-62 (2010) Article DOI: 10.1016/j.bmcl.2009.11.032 BindingDB Entry DOI: 10.7270/Q2CC11XQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 2 (Homo sapiens (Human)) | BDBM50343299 (2-((4-(2-Fluorophenyl)piperidin-1-yl)methyl)-1-met...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 22 | n/a | n/a | n/a | n/a |
Pfizer Inc. Curated by ChEMBL | Assay Description Positive allosteric modulation of rat mGluR2 expressed in HEK293 cells co-expressing Galpha15 G protein assessed as increase in glutamate-induced int... | J Med Chem 54: 1724-39 (2011) Article DOI: 10.1021/jm101414h BindingDB Entry DOI: 10.7270/Q2222V3C | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 5 (Homo sapiens (Human)) | BDBM50343299 (2-((4-(2-Fluorophenyl)piperidin-1-yl)methyl)-1-met...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | >1.58E+4 | n/a | n/a | n/a | n/a |
GlaxoSmithKline Curated by ChEMBL | Assay Description Antagonist activity at mGluR5 | Bioorg Med Chem Lett 20: 759-62 (2010) Article DOI: 10.1016/j.bmcl.2009.11.032 BindingDB Entry DOI: 10.7270/Q2CC11XQ | |||||||||||
More data for this Ligand-Target Pair |