BDBM50343352 2-hydroxy-3-(3-oxo-1-phenylbutyl)-4H-chromen-4-one::4-(4-hydroxy-2-oxo-2H-3-chromenyl)-4-phenyl-2-butanone::4-Hydroxy-3-(3-oxo-1-phenyl-butyl)-chromen-2-one::4-hydroxy-3-(3-oxo-1-phenylbutyl)-2H-chromen-2-one::CHEMBL1464::Coumadin::Jantoven::Warfarin4-Hydroxy-3-(3-oxo-1-phenyl-butyl)-chromen-2-one::wafarin::warfarin::warfarine
SMILES: CC(=O)CC(c1ccccc1)c1c(O)c2ccccc2oc1=O
InChI Key: InChIKey=PJVWKTKQMONHTI-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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Organic anion-transporting polypeptide 1D1 (Oatp1d1) (Danio rerio (Zebrafish)) | BDBM50343352 (2-hydroxy-3-(3-oxo-1-phenylbutyl)-4H-chromen-4-one...) | GoogleScholar AffyNet | Purchase CHEMBL DrugBank KEGG PC cid PC sid PDB UniChem Similars | Article PubMed | 360 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Rudjer Boskovic Institute | Assay Description In the inhibition experiments, the cells were preincubated for 20 s with test compounds, followed by a 5-min incubation with [3H]E3S (5 nM) or 30-min... | J Biol Chem 288: 33894-911 (2013) Article DOI: 10.1074/jbc.M113.518506 BindingDB Entry DOI: 10.7270/Q29Z93RK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Vitamin K epoxide reductase complex subunit 1 (rVKORC1) (Rattus norvegicus (Rat)) | BDBM50343352 (2-hydroxy-3-(3-oxo-1-phenylbutyl)-4H-chromen-4-one...) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet | Purchase CHEMBL DrugBank KEGG PC cid PC sid PDB UniChem Similars | Article PubMed | 600 | -8.82 | n/a | n/a | n/a | n/a | n/a | 7.4 | 37 |
Institut National de Recherche Agronomique (INRA)-Vetagro Sup, Veterinary School of Lyon | Assay Description Briefly, standard reactions were performed in 200 mM Hepes buffer, pH 7.4, containing 150 mM KCl, 1 mM dithiothreitol, 0.25 to 2 g liter-1... | J Biol Chem 288: 28733-42 (2013) Article DOI: 10.1074/jbc.M113.457119 BindingDB Entry DOI: 10.7270/Q27943HC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Vitamin K epoxide reductase complex subunit 1 (hVKORC1) (Homo sapiens (Human)) | BDBM50343352 (2-hydroxy-3-(3-oxo-1-phenylbutyl)-4H-chromen-4-one...) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank KEGG PC cid PC sid PDB UniChem Similars | Article PubMed | 1.80E+3 | -8.15 | n/a | n/a | n/a | n/a | n/a | 7.4 | 37 |
Institut National de Recherche Agronomique (INRA)-Vetagro Sup, Veterinary School of Lyon | Assay Description Briefly, standard reactions were performed in 200 mM Hepes buffer, pH 7.4, containing 150 mM KCl, 1 mM dithiothreitol, 0.25 to 2 g liter-1... | J Biol Chem 288: 28733-42 (2013) Article DOI: 10.1074/jbc.M113.457119 BindingDB Entry DOI: 10.7270/Q27943HC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cytochrome P450 2C9 (Homo sapiens (Human)) | BDBM50343352 (2-hydroxy-3-(3-oxo-1-phenylbutyl)-4H-chromen-4-one...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank KEGG PC cid PC sid PDB UniChem Similars | DrugBank Article PubMed | 2.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca R&D Curated by ChEMBL | Assay Description Binding affinity towards cytochrome P450 2C9 | J Med Chem 47: 907-14 (2004) Article DOI: 10.1021/jm030972s BindingDB Entry DOI: 10.7270/Q2ZK5HF3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
VKORC1-like 1 (rVKORC1L1) (Rattus norvegicus (Rat)) | BDBM50343352 (2-hydroxy-3-(3-oxo-1-phenylbutyl)-4H-chromen-4-one...) | UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL DrugBank KEGG PC cid PC sid PDB UniChem Similars | Article PubMed | 3.26E+4 | -6.36 | n/a | n/a | n/a | n/a | n/a | 7.4 | 37 |
Institut National de Recherche Agronomique (INRA)-Vetagro Sup, Veterinary School of Lyon | Assay Description Briefly, standard reactions were performed in 200 mM Hepes buffer, pH 7.4, containing 150 mM KCl, 1 mM dithiothreitol, 0.25 to 2 g liter-1... | J Biol Chem 288: 28733-42 (2013) Article DOI: 10.1074/jbc.M113.457119 BindingDB Entry DOI: 10.7270/Q27943HC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
VKORC1-like 1 (hVKORC1L1) (Homo sapiens (Human)) | BDBM50343352 (2-hydroxy-3-(3-oxo-1-phenylbutyl)-4H-chromen-4-one...) | UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL DrugBank KEGG PC cid PC sid PDB UniChem Similars | Article PubMed | 5.20E+4 | -6.08 | n/a | n/a | n/a | n/a | n/a | 7.4 | 37 |
Institut National de Recherche Agronomique (INRA)-Vetagro Sup, Veterinary School of Lyon | Assay Description Briefly, standard reactions were performed in 200 mM Hepes buffer, pH 7.4, containing 150 mM KCl, 1 mM dithiothreitol, 0.25 to 2 g liter-1... | J Biol Chem 288: 28733-42 (2013) Article DOI: 10.1074/jbc.M113.457119 BindingDB Entry DOI: 10.7270/Q27943HC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serum albumin (Homo sapiens (Human)) | BDBM50343352 (2-hydroxy-3-(3-oxo-1-phenylbutyl)-4H-chromen-4-one...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank KEGG PC cid PC sid PDB UniChem Similars | DrugBank PDB Article PubMed | n/a | n/a | n/a | 1.20E+4 | n/a | n/a | n/a | n/a | n/a |
Genentech Inc. Curated by ChEMBL | Assay Description Binding affinity to human serum albumin at 37 degC by surface plasmon resonance assay | J Med Chem 54: 2592-601 (2011) Article DOI: 10.1021/jm1008924 BindingDB Entry DOI: 10.7270/Q2NS0V6G | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Serum albumin (Rattus norvegicus) | BDBM50343352 (2-hydroxy-3-(3-oxo-1-phenylbutyl)-4H-chromen-4-one...) | Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL DrugBank KEGG PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | n/a | 9.50E+4 | n/a | n/a | n/a | n/a | n/a |
Genentech Inc. Curated by ChEMBL | Assay Description Binding affinity to rat serum albumin at 37 degC by surface plasmon resonance assay | J Med Chem 54: 2592-601 (2011) Article DOI: 10.1021/jm1008924 BindingDB Entry DOI: 10.7270/Q2NS0V6G | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Subtilisin/kexin type 7 (Homo sapiens (Human)) | BDBM50343352 (2-hydroxy-3-(3-oxo-1-phenylbutyl)-4H-chromen-4-one...) | KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank KEGG PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 2.46E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Universidade Estadual Paulista Curated by ChEMBL | Assay Description Inhibition of recombinant type 8 subtilisin using Arg-Glu-(EDANS)- Ser-Gln-Asn-Tyr-Pro-Ile-Val-Gln-Lys-(DALBCYL)-Arg fluorogenic substrate preincubat... | J Nat Prod 74: 1353-7 (2011) Article DOI: 10.1021/np1005983 BindingDB Entry DOI: 10.7270/Q2PZ596S | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serum albumin (Homo sapiens (Human)) | BDBM50343352 (2-hydroxy-3-(3-oxo-1-phenylbutyl)-4H-chromen-4-one...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank KEGG PC cid PC sid PDB UniChem Similars | DrugBank PDB Article PubMed | n/a | n/a | n/a | 4.68E+3 | n/a | n/a | n/a | n/a | n/a |
Universitat de Barcelona Curated by ChEMBL | Assay Description Binding affinity to human serum albumin by PAMPA method | J Med Chem 51: 2009-17 (2008) Article DOI: 10.1021/jm7012826 BindingDB Entry DOI: 10.7270/Q28053XB | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Bile salt export pump (Homo sapiens (Human)) | BDBM50343352 (2-hydroxy-3-(3-oxo-1-phenylbutyl)-4H-chromen-4-one...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank KEGG PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 1.15E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca Curated by ChEMBL | Assay Description Tested in vitro for dopamine(DA) neuronal uptake inhibition | Drug Metab Dispos 40: 2332-41 (2012) Article DOI: 10.1124/dmd.112.047068 BindingDB Entry DOI: 10.7270/Q2ZP488M | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serum albumin (Homo sapiens (Human)) | BDBM50343352 (2-hydroxy-3-(3-oxo-1-phenylbutyl)-4H-chromen-4-one...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank KEGG PC cid PC sid PDB UniChem Similars | DrugBank PDB Article PubMed | n/a | n/a | n/a | 2.00E+3 | n/a | n/a | n/a | n/a | n/a |
Genentech Inc. Curated by ChEMBL | Assay Description Binding affinity to human serum albumin at 20 degC by isothermal titration calorimetry analysis | J Med Chem 54: 2592-601 (2011) Article DOI: 10.1021/jm1008924 BindingDB Entry DOI: 10.7270/Q2NS0V6G | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Serum albumin (Rattus norvegicus) | BDBM50343352 (2-hydroxy-3-(3-oxo-1-phenylbutyl)-4H-chromen-4-one...) | Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL DrugBank KEGG PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | n/a | 2.00E+4 | n/a | n/a | n/a | n/a | n/a |
Genentech Inc. Curated by ChEMBL | Assay Description Binding affinity to low-affinity binding site of rat serum albumin at 20 degC by surface plasmon resonance assay | J Med Chem 54: 2592-601 (2011) Article DOI: 10.1021/jm1008924 BindingDB Entry DOI: 10.7270/Q2NS0V6G | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Vitamin K epoxide reductase complex subunit 1 (hVKORC1) (Homo sapiens (Human)) | BDBM50343352 (2-hydroxy-3-(3-oxo-1-phenylbutyl)-4H-chromen-4-one...) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank KEGG PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 8.80 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Queensland Curated by ChEMBL | Assay Description Inhibition of VKOR (unknown origin) in HEK293 expressing FIXgla-PC incubated for 48 hrs by ELISA | Bioorg Med Chem Lett 29: 1954-1956 (2019) Article DOI: 10.1016/j.bmcl.2019.05.039 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serum albumin (Rattus norvegicus) | BDBM50343352 (2-hydroxy-3-(3-oxo-1-phenylbutyl)-4H-chromen-4-one...) | Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL DrugBank KEGG PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | n/a | 9.00E+5 | n/a | n/a | n/a | n/a | n/a |
Genentech Inc. Curated by ChEMBL | Assay Description Binding affinity to high-affinity binding site of rat serum albumin at 20 degC by surface plasmon resonance assay | J Med Chem 54: 2592-601 (2011) Article DOI: 10.1021/jm1008924 BindingDB Entry DOI: 10.7270/Q2NS0V6G | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serum albumin (Homo sapiens (Human)) | BDBM50343352 (2-hydroxy-3-(3-oxo-1-phenylbutyl)-4H-chromen-4-one...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank KEGG PC cid PC sid PDB UniChem Similars | DrugBank PDB Article PubMed | n/a | n/a | n/a | 5.10E+5 | n/a | n/a | n/a | n/a | n/a |
Genentech Inc. Curated by ChEMBL | Assay Description Binding affinity to high-affinity binding site of human serum albumin at 20 degC by surface plasmon resonance assay | J Med Chem 54: 2592-601 (2011) Article DOI: 10.1021/jm1008924 BindingDB Entry DOI: 10.7270/Q2NS0V6G | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Serum albumin (Rattus norvegicus) | BDBM50343352 (2-hydroxy-3-(3-oxo-1-phenylbutyl)-4H-chromen-4-one...) | Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL DrugBank KEGG PC cid PC sid PDB UniChem Similars | PubMed | n/a | n/a | n/a | 9.31E+3 | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Curated by ChEMBL | Assay Description Binding affinity to Wistar rat serum albumin | Drug Metab Dispos 39: 312-21 (2011) BindingDB Entry DOI: 10.7270/Q2J104Z4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serum albumin (Homo sapiens (Human)) | BDBM50343352 (2-hydroxy-3-(3-oxo-1-phenylbutyl)-4H-chromen-4-one...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank KEGG PC cid PC sid PDB UniChem Similars | DrugBank PDB Article PubMed | n/a | n/a | n/a | 5.40E+3 | n/a | n/a | n/a | n/a | n/a |
Genentech Inc. Curated by ChEMBL | Assay Description Binding affinity to low-affinity binding site of human serum albumin at 20 degC by surface plasmon resonance assay | J Med Chem 54: 2592-601 (2011) Article DOI: 10.1021/jm1008924 BindingDB Entry DOI: 10.7270/Q2NS0V6G | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) |