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SMILES: CCNC(=O)Nc1ccc(cc1)-c1nc2CCOCc2c(n1)N1CCOCC1

InChI Key: InChIKey=YRPYSBTYOXXVGG-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50343761   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))		BDBM50343761
PNG
(1-ethyl-3-(4-(4-morpholino-7,8-dihydro-5H-pyrano[4...)
Show SMILES CCNC(=O)Nc1ccc(cc1)-c1nc2CCOCc2c(n1)N1CCOCC1
Show InChI InChI=1S/C20H25N5O3/c1-2-21-20(26)22-15-5-3-14(4-6-15)18-23-17-7-10-28-13-16(17)19(24-18)25-8-11-27-12-9-25/h3-6H,2,7-13H2,1H3,(H2,21,22,26)
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Article
PubMed
 25n/an/an/an/an/an/an/an/a



Genentech

Curated by ChEMBL


Assay Description
Inhibition of human recombinant mTOR expressed in insect cells using 4E-BP1 substrate after 30 mins by fluorescence resonance energy transfer assay

J Med Chem 54: 3426-35 (2011)


Article DOI: 10.1021/jm200215y
BindingDB Entry DOI: 10.7270/Q29C6XRH
More data for this
Ligand-Target Pair