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SMILES: CCNC(=O)Nc1ccc(cc1)-c1nc2c(CO[C@]2(C)CCN(C)C)c(n1)N1CCOC[C@@H]1C

InChI Key: InChIKey=YXCSOVNWVXUYBY-SSOJOUAXSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50343783   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))		BDBM50343783
PNG
(1-(4-((R)-7-(2-(Dimethylamino)ethyl)-7-methyl-4-((...)
Show SMILES CCNC(=O)Nc1ccc(cc1)-c1nc2c(CO[C@]2(C)CCN(C)C)c(n1)N1CCOC[C@@H]1C |r|
Show InChI InChI=1S/C25H36N6O3/c1-6-26-24(32)27-19-9-7-18(8-10-19)22-28-21-20(16-34-25(21,3)11-12-30(4)5)23(29-22)31-13-14-33-15-17(31)2/h7-10,17H,6,11-16H2,1-5H3,(H2,26,27,32)/t17-,25+/m0/s1
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MMDB

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Similars
Article
PubMed
 62n/an/an/an/an/an/an/an/a



Genentech

Curated by ChEMBL


Assay Description
Inhibition of human recombinant mTOR expressed in insect cells using 4E-BP1 substrate after 30 mins by fluorescence resonance energy transfer assay

J Med Chem 54: 3426-35 (2011)


Article DOI: 10.1021/jm200215y
BindingDB Entry DOI: 10.7270/Q29C6XRH
More data for this
Ligand-Target Pair