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SMILES: CC[C@@H]1C[C@H](CN(Cc2nc(oc2C)-c2ccccc2)C1)C(=O)NC[C@H]1CCCO1

InChI Key: InChIKey=NUPZHCQDIVOSOI-HMXCVIKNSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50344020   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B


(Homo sapiens (Human))		BDBM50344020
PNG
(CHEMBL1780116 | trans-(3R,5R)-5-ethyl-1-((5-methyl...)
Show SMILES CC[C@@H]1C[C@H](CN(Cc2nc(oc2C)-c2ccccc2)C1)C(=O)NC[C@H]1CCCO1 |r|
Show InChI InChI=1S/C24H33N3O3/c1-3-18-12-20(23(28)25-13-21-10-7-11-29-21)15-27(14-18)16-22-17(2)30-24(26-22)19-8-5-4-6-9-19/h4-6,8-9,18,20-21H,3,7,10-16H2,1-2H3,(H,25,28)/t18-,20-,21-/m1/s1
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Similars
Article
PubMed
n/an/a 2.91n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of PDE8B

Bioorg Med Chem Lett 21: 3095-8 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.022
BindingDB Entry DOI: 10.7270/Q20002F8
More data for this
Ligand-Target Pair