BDBM50344125 CHEMBL1778188::[6-(2,4-Difluoro-phenoxy)-1H-pyrazolo[3,4-d]pyrimidin-3-yl]-(1,1-dioxo-tetrahydro-1lambda*6*-thiophen-3-yl)-amine

SMILES: Fc1ccc(Oc2ncc3c(NC4CCS(=O)(=O)C4)[nH]nc3n2)c(F)c1

InChI Key: InChIKey=ZQRQQGXMLHABMC-UHFFFAOYSA-N

Data: 1 IC50

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Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50344125   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM50344125 (CHEMBL1778188 | [6-(2,4-Difluoro-phenoxy)-1H-pyraz...) Show SMILES Fc1ccc(Oc2ncc3c(NC4CCS(=O)(=O)C4)[nH]nc3n2)c(F)c1 Show InChI InChI=1S/C15H13F2N5O3S/c16-8-1-2-12(11(17)5-8)25-15-18-6-10-13(21-22-14(10)20-15)19-9-3-4-26(23,24)7-9/h1-2,5-6,9H,3-4,7H2,(H2,18,19,20,21,22)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	795	n/a	n/a	n/a	n/a	n/a	n/a
Roche Palo Alto Curated by ChEMBL					Assay Description Inhibition of p38alpha assessed as [33P]gamma-ATP incorporation into myelin basic protein				Bioorg Med Chem Lett 21: 3452-6 (2011) Article DOI: 10.1016/j.bmcl.2011.03.098 BindingDB Entry DOI: 10.7270/Q26H4HR7
					More data for this Ligand-Target Pair