BDBM50344136 CHEMBL1778100::N-(6-(2,4-difluorophenoxy)-1H-pyrazolo[3,4-d]pyrimidin-3-yl)cyclopentanecarboxamide

SMILES: Fc1ccc(Oc2ncc3c(NC(=O)C4CCCC4)[nH]nc3n2)c(F)c1

InChI Key: InChIKey=YIUXEBHDDTWONL-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50344136   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM50344136 (CHEMBL1778100 | N-(6-(2,4-difluorophenoxy)-1H-pyra...) Show SMILES Fc1ccc(Oc2ncc3c(NC(=O)C4CCCC4)[nH]nc3n2)c(F)c1 Show InChI InChI=1S/C17H15F2N5O2/c18-10-5-6-13(12(19)7-10)26-17-20-8-11-14(23-24-15(11)22-17)21-16(25)9-3-1-2-4-9/h5-9H,1-4H2,(H2,20,21,22,23,24,25)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	420	n/a	n/a	n/a	n/a	n/a	n/a
Roche Palo Alto Curated by ChEMBL					Assay Description Inhibition of p38alpha assessed as [33P]gamma-ATP incorporation into myelin basic protein				Bioorg Med Chem Lett 21: 3452-6 (2011) Article DOI: 10.1016/j.bmcl.2011.03.098 BindingDB Entry DOI: 10.7270/Q26H4HR7
					More data for this Ligand-Target Pair