BDBM50344137 CHEMBL1778099::N-(6-(2,4-difluorophenoxy)-1H-pyrazolo[3,4-d]pyrimidin-3-yl)isobutyramide

SMILES: CC(C)C(=O)Nc1[nH]nc2nc(Oc3ccc(F)cc3F)ncc12

InChI Key: InChIKey=ARMACDTZHMYUNQ-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50344137   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM50344137 (CHEMBL1778099 | N-(6-(2,4-difluorophenoxy)-1H-pyra...) Show SMILES CC(C)C(=O)Nc1[nH]nc2nc(Oc3ccc(F)cc3F)ncc12 Show InChI InChI=1S/C15H13F2N5O2/c1-7(2)14(23)19-12-9-6-18-15(20-13(9)22-21-12)24-11-4-3-8(16)5-10(11)17/h3-7H,1-2H3,(H2,18,19,20,21,22,23)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	100	n/a	n/a	n/a	n/a	n/a	n/a
Roche Palo Alto Curated by ChEMBL					Assay Description Inhibition of p38alpha assessed as [33P]gamma-ATP incorporation into myelin basic protein				Bioorg Med Chem Lett 21: 3452-6 (2011) Article DOI: 10.1016/j.bmcl.2011.03.098 BindingDB Entry DOI: 10.7270/Q26H4HR7
					More data for this Ligand-Target Pair