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BDBM50344162 (R)-2-(7-(1-(4-fluorophenyl)-N-methylcyclopentanecarboxamido)-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl)acetic acid::CHEMBL1778388

SMILES: CN([C@@H]1CCc2c(CC(O)=O)c3ccccc3n2C1)C(=O)C1(CCCC1)c1ccc(F)cc1

InChI Key: InChIKey=UPZGABGQGJFIDG-HXUWFJFHSA-N

Data: 1 KI  3 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50344162   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
G protein-coupled receptor 44


(Homo sapiens (Human))
BDBM50344162
PNG
((R)-2-(7-(1-(4-fluorophenyl)-N-methylcyclopentanec...)
Show SMILES CN([C@@H]1CCc2c(CC(O)=O)c3ccccc3n2C1)C(=O)C1(CCCC1)c1ccc(F)cc1 |r|
Show InChI InChI=1S/C27H29FN2O3/c1-29(26(33)27(14-4-5-15-27)18-8-10-19(28)11-9-18)20-12-13-24-22(16-25(31)32)21-6-2-3-7-23(21)30(24)17-20/h2-3,6-11,20H,4-5,12-17H2,1H3,(H,31,32)/t20-/m1/s1
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Article
PubMed
1.70n/an/an/an/an/an/an/an/a



Merck Frosst

Curated by ChEMBL


Assay Description
Binding affinity to human CRTH2 receptor expressed in HEK293-EBNA cells by radioligand competition binding assay


Bioorg Med Chem Lett 21: 3471-4 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.085
BindingDB Entry DOI: 10.7270/Q2T72HSR
More data for this
Ligand-Target Pair
Cytochrome P450 3A4


(Homo sapiens (Human))
BDBM50344162
PNG
((R)-2-(7-(1-(4-fluorophenyl)-N-methylcyclopentanec...)
Show SMILES CN([C@@H]1CCc2c(CC(O)=O)c3ccccc3n2C1)C(=O)C1(CCCC1)c1ccc(F)cc1 |r|
Show InChI InChI=1S/C27H29FN2O3/c1-29(26(33)27(14-4-5-15-27)18-8-10-19(28)11-9-18)20-12-13-24-22(16-25(31)32)21-6-2-3-7-23(21)30(24)17-20/h2-3,6-11,20H,4-5,12-17H2,1H3,(H,31,32)/t20-/m1/s1
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Article
PubMed
n/an/a 3.70E+4n/an/an/an/an/an/a



Merck Frosst

Curated by ChEMBL


Assay Description
Inhibition of CYP3A4


Bioorg Med Chem Lett 21: 3471-4 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.085
BindingDB Entry DOI: 10.7270/Q2T72HSR
More data for this
Ligand-Target Pair
Cytochrome P450 2C9


(Homo sapiens (Human))
BDBM50344162
PNG
((R)-2-(7-(1-(4-fluorophenyl)-N-methylcyclopentanec...)
Show SMILES CN([C@@H]1CCc2c(CC(O)=O)c3ccccc3n2C1)C(=O)C1(CCCC1)c1ccc(F)cc1 |r|
Show InChI InChI=1S/C27H29FN2O3/c1-29(26(33)27(14-4-5-15-27)18-8-10-19(28)11-9-18)20-12-13-24-22(16-25(31)32)21-6-2-3-7-23(21)30(24)17-20/h2-3,6-11,20H,4-5,12-17H2,1H3,(H,31,32)/t20-/m1/s1
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Article
PubMed
n/an/a>5.00E+4n/an/an/an/an/an/a



Merck Frosst

Curated by ChEMBL


Assay Description
Inhibition of CYP2C9


Bioorg Med Chem Lett 21: 3471-4 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.085
BindingDB Entry DOI: 10.7270/Q2T72HSR
More data for this
Ligand-Target Pair
G protein-coupled receptor 44


(Homo sapiens (Human))
BDBM50344162
PNG
((R)-2-(7-(1-(4-fluorophenyl)-N-methylcyclopentanec...)
Show SMILES CN([C@@H]1CCc2c(CC(O)=O)c3ccccc3n2C1)C(=O)C1(CCCC1)c1ccc(F)cc1 |r|
Show InChI InChI=1S/C27H29FN2O3/c1-29(26(33)27(14-4-5-15-27)18-8-10-19(28)11-9-18)20-12-13-24-22(16-25(31)32)21-6-2-3-7-23(21)30(24)17-20/h2-3,6-11,20H,4-5,12-17H2,1H3,(H,31,32)/t20-/m1/s1
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Article
PubMed
n/an/a 4n/an/an/an/an/an/a



Merck Frosst

Curated by ChEMBL


Assay Description
Antagonist activity at human CRTH2 receptor expressed in HEK293-EBNA cells assessed as inhibition of forskolin-stimulated intracellular cAMP producti...


Bioorg Med Chem Lett 21: 3471-4 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.085
BindingDB Entry DOI: 10.7270/Q2T72HSR
More data for this
Ligand-Target Pair