BDBM50344320 6-(2-isopropyl-7-methoxypyrazolo[1,5-a]pyridin-3-yl)-4,5-dihydropyridazin-3(2H)-one::CHEMBL1779438

SMILES: COc1cccc2c(c(nn12)C(C)C)C1=NNC(=O)CC1

InChI Key: InChIKey=FQVBEABVUMCKLE-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50344320   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
cGMP-specific 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM50344320 (6-(2-isopropyl-7-methoxypyrazolo[1,5-a]pyridin-3-y...) Show SMILES COc1cccc2c(c(nn12)C(C)C)C1=NNC(=O)CC1 |t:16| Show InChI InChI=1S/C15H18N4O2/c1-9(2)15-14(10-7-8-12(20)17-16-10)11-5-4-6-13(21-3)19(11)18-15/h4-6,9H,7-8H2,1-3H3,(H,17,20)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.25E+5	n/a	n/a	n/a	n/a	n/a	n/a
Heriot-Watt University Curated by ChEMBL					Assay Description Inhibition of human PDE5A catalytic domain using cAMP/cGMP substrate				Bioorg Med Chem Lett 21: 3307-12 (2011) Article DOI: 10.1016/j.bmcl.2011.04.021 BindingDB Entry DOI: 10.7270/Q2X067C3
					More data for this Ligand-Target Pair
Phosphodiesterase 3 (PDE3) (Homo sapiens (Human))	BDBM50344320 (6-(2-isopropyl-7-methoxypyrazolo[1,5-a]pyridin-3-y...) Show SMILES COc1cccc2c(c(nn12)C(C)C)C1=NNC(=O)CC1 |t:16| Show InChI InChI=1S/C15H18N4O2/c1-9(2)15-14(10-7-8-12(20)17-16-10)11-5-4-6-13(21-3)19(11)18-15/h4-6,9H,7-8H2,1-3H3,(H,17,20)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.60E+5	n/a	n/a	n/a	n/a	n/a	n/a
Heriot-Watt University Curated by ChEMBL					Assay Description Inhibition of human PDE3A catalytic domain using cAMP/cGMP substrate				Bioorg Med Chem Lett 21: 3307-12 (2011) Article DOI: 10.1016/j.bmcl.2011.04.021 BindingDB Entry DOI: 10.7270/Q2X067C3
					More data for this Ligand-Target Pair
3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM50344320 (6-(2-isopropyl-7-methoxypyrazolo[1,5-a]pyridin-3-y...) Show SMILES COc1cccc2c(c(nn12)C(C)C)C1=NNC(=O)CC1 |t:16| Show InChI InChI=1S/C15H18N4O2/c1-9(2)15-14(10-7-8-12(20)17-16-10)11-5-4-6-13(21-3)19(11)18-15/h4-6,9H,7-8H2,1-3H3,(H,17,20)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.70E+4	n/a	n/a	n/a	n/a	n/a	n/a
Heriot-Watt University Curated by ChEMBL					Assay Description Inhibition of human PDE4B catalytic domain using cAMP/cGMP substrate				Bioorg Med Chem Lett 21: 3307-12 (2011) Article DOI: 10.1016/j.bmcl.2011.04.021 BindingDB Entry DOI: 10.7270/Q2X067C3
					More data for this Ligand-Target Pair