BDBM50344321 2-benzyl-6-(2-isopropyl-7-methoxypyrazolo[1,5-a]pyridin-3-yl)-4,5-dihydropyridazin-3(2H)-one::CHEMBL1779439

SMILES: COc1cccc2c(c(nn12)C(C)C)C1=NN(Cc2ccccc2)C(=O)CC1

InChI Key: InChIKey=XJQUCNLRBNEHNV-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50344321   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
cGMP-specific 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM50344321 (2-benzyl-6-(2-isopropyl-7-methoxypyrazolo[1,5-a]py...) Show SMILES COc1cccc2c(c(nn12)C(C)C)C1=NN(Cc2ccccc2)C(=O)CC1 |t:16| Show InChI InChI=1S/C22H24N4O2/c1-15(2)22-21(18-10-7-11-20(28-3)26(18)24-22)17-12-13-19(27)25(23-17)14-16-8-5-4-6-9-16/h4-11,15H,12-14H2,1-3H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>4.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Heriot-Watt University Curated by ChEMBL					Assay Description Inhibition of human PDE5A catalytic domain using cAMP/cGMP substrate				Bioorg Med Chem Lett 21: 3307-12 (2011) Article DOI: 10.1016/j.bmcl.2011.04.021 BindingDB Entry DOI: 10.7270/Q2X067C3
					More data for this Ligand-Target Pair
Phosphodiesterase 3 (PDE3) (Homo sapiens (Human))	BDBM50344321 (2-benzyl-6-(2-isopropyl-7-methoxypyrazolo[1,5-a]py...) Show SMILES COc1cccc2c(c(nn12)C(C)C)C1=NN(Cc2ccccc2)C(=O)CC1 |t:16| Show InChI InChI=1S/C22H24N4O2/c1-15(2)22-21(18-10-7-11-20(28-3)26(18)24-22)17-12-13-19(27)25(23-17)14-16-8-5-4-6-9-16/h4-11,15H,12-14H2,1-3H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>4.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Heriot-Watt University Curated by ChEMBL					Assay Description Inhibition of human PDE3A catalytic domain using cAMP/cGMP substrate				Bioorg Med Chem Lett 21: 3307-12 (2011) Article DOI: 10.1016/j.bmcl.2011.04.021 BindingDB Entry DOI: 10.7270/Q2X067C3
					More data for this Ligand-Target Pair
3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM50344321 (2-benzyl-6-(2-isopropyl-7-methoxypyrazolo[1,5-a]py...) Show SMILES COc1cccc2c(c(nn12)C(C)C)C1=NN(Cc2ccccc2)C(=O)CC1 |t:16| Show InChI InChI=1S/C22H24N4O2/c1-15(2)22-21(18-10-7-11-20(28-3)26(18)24-22)17-12-13-19(27)25(23-17)14-16-8-5-4-6-9-16/h4-11,15H,12-14H2,1-3H3	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
Heriot-Watt University Curated by ChEMBL					Assay Description Inhibition of human PDE4B catalytic domain using cAMP/cGMP substrate				Bioorg Med Chem Lett 21: 3307-12 (2011) Article DOI: 10.1016/j.bmcl.2011.04.021 BindingDB Entry DOI: 10.7270/Q2X067C3
					More data for this Ligand-Target Pair