BDBM50344322 3-(6-chloropyridazin-3-yl)-2-isopropylpyrazolo[1,5-a]pyridine::CHEMBL1779440

SMILES: CC(C)c1nn2ccccc2c1-c1ccc(Cl)nn1

InChI Key: InChIKey=WYMGHYURHRYYAB-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50344322   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
cGMP-specific 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM50344322 (3-(6-chloropyridazin-3-yl)-2-isopropylpyrazolo[1,5...) Show SMILES CC(C)c1nn2ccccc2c1-c1ccc(Cl)nn1 Show InChI InChI=1S/C14H13ClN4/c1-9(2)14-13(10-6-7-12(15)17-16-10)11-5-3-4-8-19(11)18-14/h3-9H,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6.50E+4	n/a	n/a	n/a	n/a	n/a	n/a
Heriot-Watt University Curated by ChEMBL					Assay Description Inhibition of human PDE5A catalytic domain using cAMP/cGMP substrate				Bioorg Med Chem Lett 21: 3307-12 (2011) Article DOI: 10.1016/j.bmcl.2011.04.021 BindingDB Entry DOI: 10.7270/Q2X067C3
					More data for this Ligand-Target Pair
Phosphodiesterase 3 (PDE3) (Homo sapiens (Human))	BDBM50344322 (3-(6-chloropyridazin-3-yl)-2-isopropylpyrazolo[1,5...) Show SMILES CC(C)c1nn2ccccc2c1-c1ccc(Cl)nn1 Show InChI InChI=1S/C14H13ClN4/c1-9(2)14-13(10-6-7-12(15)17-16-10)11-5-3-4-8-19(11)18-14/h3-9H,1-2H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>4.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Heriot-Watt University Curated by ChEMBL					Assay Description Inhibition of human PDE3A catalytic domain using cAMP/cGMP substrate				Bioorg Med Chem Lett 21: 3307-12 (2011) Article DOI: 10.1016/j.bmcl.2011.04.021 BindingDB Entry DOI: 10.7270/Q2X067C3
					More data for this Ligand-Target Pair
3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM50344322 (3-(6-chloropyridazin-3-yl)-2-isopropylpyrazolo[1,5...) Show SMILES CC(C)c1nn2ccccc2c1-c1ccc(Cl)nn1 Show InChI InChI=1S/C14H13ClN4/c1-9(2)14-13(10-6-7-12(15)17-16-10)11-5-3-4-8-19(11)18-14/h3-9H,1-2H3	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.90E+4	n/a	n/a	n/a	n/a	n/a	n/a
Heriot-Watt University Curated by ChEMBL					Assay Description Inhibition of human PDE4B catalytic domain using cAMP/cGMP substrate				Bioorg Med Chem Lett 21: 3307-12 (2011) Article DOI: 10.1016/j.bmcl.2011.04.021 BindingDB Entry DOI: 10.7270/Q2X067C3
					More data for this Ligand-Target Pair