BDBM50344527 4-(2-(4-isopropylphenylamino)benzo[d]thiazol-5-yloxy)-N-methylpicolinamide::CHEMBL1778408

SMILES: CNC(=O)c1cc(Oc2ccc3sc(Nc4ccc(cc4)C(C)C)nc3c2)ccn1

InChI Key: InChIKey=RMQLQVJFCNMQCX-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50344527   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
RAF proto-oncogene serine/threonine-protein kinase (Homo sapiens (Human))	BDBM50344527 (4-(2-(4-isopropylphenylamino)benzo[d]thiazol-5-ylo...) Show SMILES CNC(=O)c1cc(Oc2ccc3sc(Nc4ccc(cc4)C(C)C)nc3c2)ccn1 Show InChI InChI=1S/C23H22N4O2S/c1-14(2)15-4-6-16(7-5-15)26-23-27-19-12-17(8-9-21(19)30-23)29-18-10-11-25-20(13-18)22(28)24-3/h4-14H,1-3H3,(H,24,28)(H,26,27)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institutes for Biomedical Research Curated by ChEMBL					Assay Description Inhibition of c-Raf assessed as phosphorylation of MEK1/2 by ELISA				Bioorg Med Chem Lett 21: 3286-9 (2011) Article DOI: 10.1016/j.bmcl.2011.04.023 BindingDB Entry DOI: 10.7270/Q2R78FH0
					More data for this Ligand-Target Pair