BDBM50344650 8-(2-(diethylamino)ethoxy)-6,6-dimethyl-3-(trifluoromethyl)benzo[d]naphtho[2,3-b]furan-11(6H)-one::CHEMBL1779188

SMILES: CCN(CC)CCOc1ccc2C(=O)c3c(oc4cc(ccc34)C(F)(F)F)C(C)(C)c2c1

InChI Key: InChIKey=NLNVEQTXFMQFOE-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50344650   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
ALK tyrosine kinase receptor (Homo sapiens (Human))	BDBM50344650 (8-(2-(diethylamino)ethoxy)-6,6-dimethyl-3-(trifluo...) Show SMILES CCN(CC)CCOc1ccc2C(=O)c3c(oc4cc(ccc34)C(F)(F)F)C(C)(C)c2c1 Show InChI InChI=1S/C25H26F3NO3/c1-5-29(6-2)11-12-31-16-8-10-17-19(14-16)24(3,4)23-21(22(17)30)18-9-7-15(25(26,27)28)13-20(18)32-23/h7-10,13-14H,5-6,11-12H2,1-4H3	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.47E+3	n/a	n/a	n/a	n/a	n/a	n/a
Chugai Pharmaceutical Co. Ltd. Curated by ChEMBL					Assay Description Inhibition of ALK assessed as biotin-EGPWLEEEEEAYGWMDF peptide phosphorylation by TR-FRET assay				Bioorg Med Chem Lett 21: 3788-93 (2011) Checked by Author Article DOI: 10.1016/j.bmcl.2011.04.020 BindingDB Entry DOI: 10.7270/Q2Q81DF2
					More data for this Ligand-Target Pair