BDBM50344913 (R)-5-(1-(3,4-difluorobenzyl)-5-ethyl-7-isopropyl-4-oxo-4,5,7,8-tetrahydro-1H-imidazo[2,1-b]purin-2-yl)picolinonitrile::CHEMBL1777948
SMILES: CCN1C2=N[C@@H](CN2c2c(nc(-c3ccc(nc3)C#N)n2Cc2ccc(F)c(F)c2)C1=O)C(C)C
InChI Key: InChIKey=WIXWENZRZIOJSK-FQEVSTJZSA-N
Data: 1 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
P2X purinoceptor 7 (Homo sapiens (Human)) | BDBM50344913 ((R)-5-(1-(3,4-difluorobenzyl)-5-ethyl-7-isopropyl-...) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 41 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories Curated by ChEMBL | Assay Description Antagonist activity at human P2X7 receptor by calcium flux assay | Bioorg Med Chem Lett 21: 3805-8 (2011) Article DOI: 10.1016/j.bmcl.2011.04.034 BindingDB Entry DOI: 10.7270/Q25B02SR | |||||||||||
More data for this Ligand-Target Pair |