BDBM50345444 CHEMBL1784725::Ethyl 8-oxo-8H-acenaphtho[1,2-b]pyrrole-9-carboxylate

SMILES: CCOC(=O)c1c2c3cccc4cccc(c2nc1=O)c34

InChI Key: InChIKey=CEEHIKQKZBQZLL-UHFFFAOYSA-N

Data: 18 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 18 hits for monomerid = 50345444   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Macrophage-stimulating protein receptor (Homo sapiens (Human))	BDBM50345444 (CHEMBL1784725 | Ethyl 8-oxo-8H-acenaphtho[1,2-b]py...) Show SMILES CCOC(=O)c1c2c3cccc4cccc(c2nc1=O)c34 Show InChI InChI=1S/C17H11NO3/c1-2-21-17(20)14-13-10-7-3-5-9-6-4-8-11(12(9)10)15(13)18-16(14)19/h3-8H,2H2,1H3	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
East China University of Science and Technology Curated by ChEMBL					Assay Description Inhibition of RON expressed in Bac-to-Bac Baculovirus expression system using poly(Glu-Tyr)4:1 as substrate after 60 mins by ELISA				J Med Chem 54: 3732-45 (2011) Article DOI: 10.1021/jm200258t BindingDB Entry DOI: 10.7270/Q29W0FTH
					More data for this Ligand-Target Pair
Insulin-like growth factor I receptor (Homo sapiens (Human))	BDBM50345444 (CHEMBL1784725 | Ethyl 8-oxo-8H-acenaphtho[1,2-b]py...) Show SMILES CCOC(=O)c1c2c3cccc4cccc(c2nc1=O)c34 Show InChI InChI=1S/C17H11NO3/c1-2-21-17(20)14-13-10-7-3-5-9-6-4-8-11(12(9)10)15(13)18-16(14)19/h3-8H,2H2,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
East China University of Science and Technology Curated by ChEMBL					Assay Description Inhibition of IGF1R expressed in Bac-to-Bac Baculovirus expression system using poly(Glu-Tyr)4:1 as substrate after 60 mins by ELISA				J Med Chem 54: 3732-45 (2011) Article DOI: 10.1021/jm200258t BindingDB Entry DOI: 10.7270/Q29W0FTH
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 2 (Homo sapiens (Human))	BDBM50345444 (CHEMBL1784725 | Ethyl 8-oxo-8H-acenaphtho[1,2-b]py...) Show SMILES CCOC(=O)c1c2c3cccc4cccc(c2nc1=O)c34 Show InChI InChI=1S/C17H11NO3/c1-2-21-17(20)14-13-10-7-3-5-9-6-4-8-11(12(9)10)15(13)18-16(14)19/h3-8H,2H2,1H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
East China University of Science and Technology Curated by ChEMBL					Assay Description Inhibition of FGFR2 using poly(Glu-Tyr)4:1 as substrate after 60 mins by ELISA				J Med Chem 54: 3732-45 (2011) Article DOI: 10.1021/jm200258t BindingDB Entry DOI: 10.7270/Q29W0FTH
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 3 (Homo sapiens (Human))	BDBM50345444 (CHEMBL1784725 | Ethyl 8-oxo-8H-acenaphtho[1,2-b]py...) Show SMILES CCOC(=O)c1c2c3cccc4cccc(c2nc1=O)c34 Show InChI InChI=1S/C17H11NO3/c1-2-21-17(20)14-13-10-7-3-5-9-6-4-8-11(12(9)10)15(13)18-16(14)19/h3-8H,2H2,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
East China University of Science and Technology Curated by ChEMBL					Assay Description Inhibition of FGFR3 using poly(Glu-Tyr)4:1 as substrate after 60 mins by ELISA				J Med Chem 54: 3732-45 (2011) Article DOI: 10.1021/jm200258t BindingDB Entry DOI: 10.7270/Q29W0FTH
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 4 (Homo sapiens (Human))	BDBM50345444 (CHEMBL1784725 | Ethyl 8-oxo-8H-acenaphtho[1,2-b]py...) Show SMILES CCOC(=O)c1c2c3cccc4cccc(c2nc1=O)c34 Show InChI InChI=1S/C17H11NO3/c1-2-21-17(20)14-13-10-7-3-5-9-6-4-8-11(12(9)10)15(13)18-16(14)19/h3-8H,2H2,1H3	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
East China University of Science and Technology Curated by ChEMBL					Assay Description Inhibition of FGFR4 using poly(Glu-Tyr)4:1 as substrate after 60 mins by ELISA				J Med Chem 54: 3732-45 (2011) Article DOI: 10.1021/jm200258t BindingDB Entry DOI: 10.7270/Q29W0FTH
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 1 (Homo sapiens (Human))	BDBM50345444 (CHEMBL1784725 | Ethyl 8-oxo-8H-acenaphtho[1,2-b]py...) Show SMILES CCOC(=O)c1c2c3cccc4cccc(c2nc1=O)c34 Show InChI InChI=1S/C17H11NO3/c1-2-21-17(20)14-13-10-7-3-5-9-6-4-8-11(12(9)10)15(13)18-16(14)19/h3-8H,2H2,1H3	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
East China University of Science and Technology Curated by ChEMBL					Assay Description Inhibition of VEGFR1 using poly(Glu-Tyr)4:1 as substrate measured after 60 mins by ELISA				J Med Chem 54: 3732-45 (2011) Article DOI: 10.1021/jm200258t BindingDB Entry DOI: 10.7270/Q29W0FTH
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50345444 (CHEMBL1784725 | Ethyl 8-oxo-8H-acenaphtho[1,2-b]py...) Show SMILES CCOC(=O)c1c2c3cccc4cccc(c2nc1=O)c34 Show InChI InChI=1S/C17H11NO3/c1-2-21-17(20)14-13-10-7-3-5-9-6-4-8-11(12(9)10)15(13)18-16(14)19/h3-8H,2H2,1H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
East China University of Science and Technology Curated by ChEMBL					Assay Description Inhibition of VEGFR2 expressed in Bac-to-Bac Baculovirus expression system using poly(Glu-Tyr)4:1 as substrate after 60 mins by ELISA				J Med Chem 54: 3732-45 (2011) Article DOI: 10.1021/jm200258t BindingDB Entry DOI: 10.7270/Q29W0FTH
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor alpha (Homo sapiens (Human))	BDBM50345444 (CHEMBL1784725 | Ethyl 8-oxo-8H-acenaphtho[1,2-b]py...) Show SMILES CCOC(=O)c1c2c3cccc4cccc(c2nc1=O)c34 Show InChI InChI=1S/C17H11NO3/c1-2-21-17(20)14-13-10-7-3-5-9-6-4-8-11(12(9)10)15(13)18-16(14)19/h3-8H,2H2,1H3	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
East China University of Science and Technology Curated by ChEMBL					Assay Description Inhibition of PDGFRalpha using poly(Glu-Tyr)4:1 as substrate after 60 mins by ELISA				J Med Chem 54: 3732-45 (2011) Article DOI: 10.1021/jm200258t BindingDB Entry DOI: 10.7270/Q29W0FTH
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor beta (Homo sapiens (Human))	BDBM50345444 (CHEMBL1784725 | Ethyl 8-oxo-8H-acenaphtho[1,2-b]py...) Show SMILES CCOC(=O)c1c2c3cccc4cccc(c2nc1=O)c34 Show InChI InChI=1S/C17H11NO3/c1-2-21-17(20)14-13-10-7-3-5-9-6-4-8-11(12(9)10)15(13)18-16(14)19/h3-8H,2H2,1H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
East China University of Science and Technology Curated by ChEMBL					Assay Description Inhibition of PDGFRbeta using poly(Glu-Tyr)4:1 as substrate after 60 mins by ELISA				J Med Chem 54: 3732-45 (2011) Article DOI: 10.1021/jm200258t BindingDB Entry DOI: 10.7270/Q29W0FTH
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit (Homo sapiens (Human))	BDBM50345444 (CHEMBL1784725 | Ethyl 8-oxo-8H-acenaphtho[1,2-b]py...) Show SMILES CCOC(=O)c1c2c3cccc4cccc(c2nc1=O)c34 Show InChI InChI=1S/C17H11NO3/c1-2-21-17(20)14-13-10-7-3-5-9-6-4-8-11(12(9)10)15(13)18-16(14)19/h3-8H,2H2,1H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
East China University of Science and Technology Curated by ChEMBL					Assay Description Inhibition of c-kit expressed in Bac-to-Bac Baculovirus expression system using poly(Glu-Tyr)4:1 as substrate after 60 mins by ELISA				J Med Chem 54: 3732-45 (2011) Article DOI: 10.1021/jm200258t BindingDB Entry DOI: 10.7270/Q29W0FTH
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret (Homo sapiens (Human))	BDBM50345444 (CHEMBL1784725 | Ethyl 8-oxo-8H-acenaphtho[1,2-b]py...) Show SMILES CCOC(=O)c1c2c3cccc4cccc(c2nc1=O)c34 Show InChI InChI=1S/C17H11NO3/c1-2-21-17(20)14-13-10-7-3-5-9-6-4-8-11(12(9)10)15(13)18-16(14)19/h3-8H,2H2,1H3	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
East China University of Science and Technology Curated by ChEMBL					Assay Description Inhibition of RET expressed in Bac-to-Bac Baculovirus expression system using poly(Glu-Tyr)4:1 as substrate after 60 mins by ELISA				J Med Chem 54: 3732-45 (2011) Article DOI: 10.1021/jm200258t BindingDB Entry DOI: 10.7270/Q29W0FTH
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM50345444 (CHEMBL1784725 | Ethyl 8-oxo-8H-acenaphtho[1,2-b]py...) Show SMILES CCOC(=O)c1c2c3cccc4cccc(c2nc1=O)c34 Show InChI InChI=1S/C17H11NO3/c1-2-21-17(20)14-13-10-7-3-5-9-6-4-8-11(12(9)10)15(13)18-16(14)19/h3-8H,2H2,1H3	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
East China University of Science and Technology Curated by ChEMBL					Assay Description Inhibition of EGFR2 using poly(Glu-Tyr)4:1 as substrate after 60 mins by ELISA				J Med Chem 54: 3732-45 (2011) Article DOI: 10.1021/jm200258t BindingDB Entry DOI: 10.7270/Q29W0FTH
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human))	BDBM50345444 (CHEMBL1784725 | Ethyl 8-oxo-8H-acenaphtho[1,2-b]py...) Show SMILES CCOC(=O)c1c2c3cccc4cccc(c2nc1=O)c34 Show InChI InChI=1S/C17H11NO3/c1-2-21-17(20)14-13-10-7-3-5-9-6-4-8-11(12(9)10)15(13)18-16(14)19/h3-8H,2H2,1H3	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
East China University of Science and Technology Curated by ChEMBL					Assay Description Inhibition of c-Src expressed in Bac-to-Bac Baculovirus expression system using poly(Glu-Tyr)4:1 as substrate after 60 mins by ELISA				J Med Chem 54: 3732-45 (2011) Article DOI: 10.1021/jm200258t BindingDB Entry DOI: 10.7270/Q29W0FTH
					More data for this Ligand-Target Pair
Tyrosine-protein kinase ABL1 (Homo sapiens (Human))	BDBM50345444 (CHEMBL1784725 | Ethyl 8-oxo-8H-acenaphtho[1,2-b]py...) Show SMILES CCOC(=O)c1c2c3cccc4cccc(c2nc1=O)c34 Show InChI InChI=1S/C17H11NO3/c1-2-21-17(20)14-13-10-7-3-5-9-6-4-8-11(12(9)10)15(13)18-16(14)19/h3-8H,2H2,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
East China University of Science and Technology Curated by ChEMBL					Assay Description Inhibition of Abl using poly(Glu-Tyr)4:1 as substrate after 60 mins by ELISA				J Med Chem 54: 3732-45 (2011) Article DOI: 10.1021/jm200258t BindingDB Entry DOI: 10.7270/Q29W0FTH
					More data for this Ligand-Target Pair
Ephrin type-A receptor 2 (Homo sapiens (Human))	BDBM50345444 (CHEMBL1784725 | Ethyl 8-oxo-8H-acenaphtho[1,2-b]py...) Show SMILES CCOC(=O)c1c2c3cccc4cccc(c2nc1=O)c34 Show InChI InChI=1S/C17H11NO3/c1-2-21-17(20)14-13-10-7-3-5-9-6-4-8-11(12(9)10)15(13)18-16(14)19/h3-8H,2H2,1H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
East China University of Science and Technology Curated by ChEMBL					Assay Description Inhibition of EphA2 expressed in Bac-to-Bac Baculovirus expression system using poly(Glu-Tyr)4:1 as substrate after 60 mins by ELISA				J Med Chem 54: 3732-45 (2011) Article DOI: 10.1021/jm200258t BindingDB Entry DOI: 10.7270/Q29W0FTH
					More data for this Ligand-Target Pair
Ephrin type-B receptor 2 (Homo sapiens (Human))	BDBM50345444 (CHEMBL1784725 | Ethyl 8-oxo-8H-acenaphtho[1,2-b]py...) Show SMILES CCOC(=O)c1c2c3cccc4cccc(c2nc1=O)c34 Show InChI InChI=1S/C17H11NO3/c1-2-21-17(20)14-13-10-7-3-5-9-6-4-8-11(12(9)10)15(13)18-16(14)19/h3-8H,2H2,1H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
East China University of Science and Technology Curated by ChEMBL					Assay Description Inhibition of EphB2 expressed in Bac-to-Bac Baculovirus expression system using poly(Glu-Tyr)4:1 as substrate after 60 mins by ELISA				J Med Chem 54: 3732-45 (2011) Article DOI: 10.1021/jm200258t BindingDB Entry DOI: 10.7270/Q29W0FTH
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM50345444 (CHEMBL1784725 | Ethyl 8-oxo-8H-acenaphtho[1,2-b]py...) Show SMILES CCOC(=O)c1c2c3cccc4cccc(c2nc1=O)c34 Show InChI InChI=1S/C17H11NO3/c1-2-21-17(20)14-13-10-7-3-5-9-6-4-8-11(12(9)10)15(13)18-16(14)19/h3-8H,2H2,1H3	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
East China University of Science and Technology Curated by ChEMBL					Assay Description Inhibition of c-Met expressed in Bac-to-Bac Baculovirus expression system using poly(Glu-Tyr)4:1 as substrate after 60 mins by ELISA				J Med Chem 54: 3732-45 (2011) Article DOI: 10.1021/jm200258t BindingDB Entry DOI: 10.7270/Q29W0FTH
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 1 (Homo sapiens (Human))	BDBM50345444 (CHEMBL1784725 | Ethyl 8-oxo-8H-acenaphtho[1,2-b]py...) Show SMILES CCOC(=O)c1c2c3cccc4cccc(c2nc1=O)c34 Show InChI InChI=1S/C17H11NO3/c1-2-21-17(20)14-13-10-7-3-5-9-6-4-8-11(12(9)10)15(13)18-16(14)19/h3-8H,2H2,1H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	74	n/a	n/a	n/a	n/a	n/a	n/a
East China University of Science and Technology Curated by ChEMBL					Assay Description Inhibition of FGFR1 using poly(Glu-Tyr)4:1 as substrate after 60 mins by ELISA				J Med Chem 54: 3732-45 (2011) Article DOI: 10.1021/jm200258t BindingDB Entry DOI: 10.7270/Q29W0FTH
					More data for this Ligand-Target Pair