BDBM50345449 8-Oxo-3-(2-(pyrazin-2-yl)ethylthio)-8H-acenaphtho[1,2-b]pyrrole-9-carbonitrile::CHEMBL1782083

SMILES: O=c1nc2c3cccc4c(SCCc5cnccn5)ccc(c2c1C#N)c34

InChI Key: InChIKey=HQIOKZBKQHBBHC-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50345449   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Fibroblast growth factor receptor 1 (Homo sapiens (Human))	BDBM50345449 (8-Oxo-3-(2-(pyrazin-2-yl)ethylthio)-8H-acenaphtho[...) Show SMILES O=c1nc2c3cccc4c(SCCc5cnccn5)ccc(c2c1C#N)c34 Show InChI InChI=1S/C21H12N4OS/c22-10-16-19-14-4-5-17(27-9-6-12-11-23-7-8-24-12)13-2-1-3-15(18(13)14)20(19)25-21(16)26/h1-5,7-8,11H,6,9H2	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
East China University of Science and Technology Curated by ChEMBL					Assay Description Inhibition of FGFR1 using poly(Glu-Tyr)4:1 as substrate after 60 mins by ELISA				J Med Chem 54: 3732-45 (2011) Article DOI: 10.1021/jm200258t BindingDB Entry DOI: 10.7270/Q29W0FTH
					More data for this Ligand-Target Pair