BDBM50345452 3-(1-(5-Methyl-1,3-oxathiolan-5-yl)ethylthio)-8-oxo-8Hacenaphtho[1,2-b]pyrrole-9-carbonitrile::CHEMBL1784723
SMILES: CC(Sc1ccc2c3c(C#N)c(=O)nc3c3cccc1c23)C1(C)CSCO1
InChI Key: InChIKey=YREXMLYSGAVCFK-UHFFFAOYSA-N
Data: 1 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Fibroblast growth factor receptor 1 (Homo sapiens (Human)) | BDBM50345452 (3-(1-(5-Methyl-1,3-oxathiolan-5-yl)ethylthio)-8-ox...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 3.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
East China University of Science and Technology Curated by ChEMBL | Assay Description Inhibition of FGFR1 using poly(Glu-Tyr)4:1 as substrate after 60 mins by ELISA | J Med Chem 54: 3732-45 (2011) Article DOI: 10.1021/jm200258t BindingDB Entry DOI: 10.7270/Q29W0FTH | |||||||||||
More data for this Ligand-Target Pair |