BDBM50345456 CHEMBL1784728::Ethyl 3-(Isopropylthio)-8-oxo-8H-acenaphtho[1,2-b]pyrrole-9-carboxylate

SMILES: CCOC(=O)c1c2c3ccc(SC(C)C)c4cccc(c2nc1=O)c34

InChI Key: InChIKey=VSGCPWMJKYOMGV-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50345456   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Fibroblast growth factor receptor 1 (Homo sapiens (Human))	BDBM50345456 (CHEMBL1784728 | Ethyl 3-(Isopropylthio)-8-oxo-8H-a...) Show SMILES CCOC(=O)c1c2c3ccc(SC(C)C)c4cccc(c2nc1=O)c34 Show InChI InChI=1S/C20H17NO3S/c1-4-24-20(23)17-16-12-8-9-14(25-10(2)3)11-6-5-7-13(15(11)12)18(16)21-19(17)22/h5-10H,4H2,1-3H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
East China University of Science and Technology Curated by ChEMBL					Assay Description Inhibition of FGFR1 using poly(Glu-Tyr)4:1 as substrate after 60 mins by ELISA				J Med Chem 54: 3732-45 (2011) Article DOI: 10.1021/jm200258t BindingDB Entry DOI: 10.7270/Q29W0FTH
					More data for this Ligand-Target Pair