BDBM50345457 CHEMBL1784729::Ethyl 8-Oxo-3-(2-(pyrazin-2-yl)ethylthio)-8H-acenaphtho[1,2-b]pyrrole-9-carboxylate

SMILES: CCOC(=O)c1c2c3ccc(SCCc4cnccn4)c4cccc(c2nc1=O)c34

InChI Key: InChIKey=XTUJRWNRJGZFHG-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50345457   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Fibroblast growth factor receptor 1 (Homo sapiens (Human))	BDBM50345457 (CHEMBL1784729 | Ethyl 8-Oxo-3-(2-(pyrazin-2-yl)eth...) Show SMILES CCOC(=O)c1c2c3ccc(SCCc4cnccn4)c4cccc(c2nc1=O)c34 Show InChI InChI=1S/C23H17N3O3S/c1-2-29-23(28)20-19-15-6-7-17(30-11-8-13-12-24-9-10-25-13)14-4-3-5-16(18(14)15)21(19)26-22(20)27/h3-7,9-10,12H,2,8,11H2,1H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
East China University of Science and Technology Curated by ChEMBL					Assay Description Inhibition of FGFR1 using poly(Glu-Tyr)4:1 as substrate after 60 mins by ELISA				J Med Chem 54: 3732-45 (2011) Article DOI: 10.1021/jm200258t BindingDB Entry DOI: 10.7270/Q29W0FTH
					More data for this Ligand-Target Pair