Found 9 hits for monomerid = 50345520 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Matrix metalloproteinase-14 (MMP14)
(Homo sapiens (Human)) | BDBM50345520
(CHEMBL1784345 | N-(1-(cyclobutanecarbonyl)-4-((4-(...)Show SMILES Cc1noc(C)c1CCC1CCN(CC1)S(=O)(=O)CC1(CCN(CC1)C(=O)C1CCC1)N(O)C=O Show InChI InChI=1S/C24H38N4O6S/c1-18-22(19(2)34-25-18)7-6-20-8-12-27(13-9-20)35(32,33)16-24(28(31)17-29)10-14-26(15-11-24)23(30)21-4-3-5-21/h17,20-21,31H,3-16H2,1-2H3 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description Inhibition of recombinant human MMP-14 assessed as substrate cleavage after 20 hrs by fluorescence assay |
Bioorg Med Chem Lett 21: 3301-6 (2011)
Article DOI: 10.1016/j.bmcl.2011.04.028 BindingDB Entry DOI: 10.7270/Q2P55NVH |
More data for this Ligand-Target Pair | |
A disintegrin and metalloproteinase with thrombospondin motifs 4 (ADAMTS-4)
(Homo sapiens (Human)) | BDBM50345520
(CHEMBL1784345 | N-(1-(cyclobutanecarbonyl)-4-((4-(...)Show SMILES Cc1noc(C)c1CCC1CCN(CC1)S(=O)(=O)CC1(CCN(CC1)C(=O)C1CCC1)N(O)C=O Show InChI InChI=1S/C24H38N4O6S/c1-18-22(19(2)34-25-18)7-6-20-8-12-27(13-9-20)35(32,33)16-24(28(31)17-29)10-14-26(15-11-24)23(30)21-4-3-5-21/h17,20-21,31H,3-16H2,1-2H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description Inhibition of ADAMTS-4 assessed as substrate cleavage after 16 hrs by fluorescence assay |
Bioorg Med Chem Lett 21: 3301-6 (2011)
Article DOI: 10.1016/j.bmcl.2011.04.028 BindingDB Entry DOI: 10.7270/Q2P55NVH |
More data for this Ligand-Target Pair | |
Matrix metalloproteinase-9
(Homo sapiens (Human)) | BDBM50345520
(CHEMBL1784345 | N-(1-(cyclobutanecarbonyl)-4-((4-(...)Show SMILES Cc1noc(C)c1CCC1CCN(CC1)S(=O)(=O)CC1(CCN(CC1)C(=O)C1CCC1)N(O)C=O Show InChI InChI=1S/C24H38N4O6S/c1-18-22(19(2)34-25-18)7-6-20-8-12-27(13-9-20)35(32,33)16-24(28(31)17-29)10-14-26(15-11-24)23(30)21-4-3-5-21/h17,20-21,31H,3-16H2,1-2H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description Inhibition of recombinant human MMP-9 assessed as substrate cleavage after 20 hrs by fluorescence assay |
Bioorg Med Chem Lett 21: 3301-6 (2011)
Article DOI: 10.1016/j.bmcl.2011.04.028 BindingDB Entry DOI: 10.7270/Q2P55NVH |
More data for this Ligand-Target Pair | |
A disintegrin and metalloproteinase with thrombospondin motifs 5 (ADAMTS-5)
(Homo sapiens (Human)) | BDBM50345520
(CHEMBL1784345 | N-(1-(cyclobutanecarbonyl)-4-((4-(...)Show SMILES Cc1noc(C)c1CCC1CCN(CC1)S(=O)(=O)CC1(CCN(CC1)C(=O)C1CCC1)N(O)C=O Show InChI InChI=1S/C24H38N4O6S/c1-18-22(19(2)34-25-18)7-6-20-8-12-27(13-9-20)35(32,33)16-24(28(31)17-29)10-14-26(15-11-24)23(30)21-4-3-5-21/h17,20-21,31H,3-16H2,1-2H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 270 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description Inhibition of ADAMTS-5 assessed as substrate cleavage after 16 hrs by fluorescence assay |
Bioorg Med Chem Lett 21: 3301-6 (2011)
Article DOI: 10.1016/j.bmcl.2011.04.028 BindingDB Entry DOI: 10.7270/Q2P55NVH |
More data for this Ligand-Target Pair | |
A disintegrin and metalloproteinase with thrombospondin motifs 4 (ADAMTS-4)
(Homo sapiens (Human)) | BDBM50345520
(CHEMBL1784345 | N-(1-(cyclobutanecarbonyl)-4-((4-(...)Show SMILES Cc1noc(C)c1CCC1CCN(CC1)S(=O)(=O)CC1(CCN(CC1)C(=O)C1CCC1)N(O)C=O Show InChI InChI=1S/C24H38N4O6S/c1-18-22(19(2)34-25-18)7-6-20-8-12-27(13-9-20)35(32,33)16-24(28(31)17-29)10-14-26(15-11-24)23(30)21-4-3-5-21/h17,20-21,31H,3-16H2,1-2H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| US Patent
| n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
| Assay Description Protein concentrations were measured using the Micro BCA Protein Assay Kit (Pierce/Thermo Scientific, IL). Sample buffer was mixed with 5-25 μg ... |
Bioorg Med Chem Lett 19: 4280-3 (2009)
BindingDB Entry DOI: 10.7270/Q2BC41VN |
More data for this Ligand-Target Pair | |
Cytochrome P450 3A4
(Homo sapiens (Human)) | BDBM50345520
(CHEMBL1784345 | N-(1-(cyclobutanecarbonyl)-4-((4-(...)Show SMILES Cc1noc(C)c1CCC1CCN(CC1)S(=O)(=O)CC1(CCN(CC1)C(=O)C1CCC1)N(O)C=O Show InChI InChI=1S/C24H38N4O6S/c1-18-22(19(2)34-25-18)7-6-20-8-12-27(13-9-20)35(32,33)16-24(28(31)17-29)10-14-26(15-11-24)23(30)21-4-3-5-21/h17,20-21,31H,3-16H2,1-2H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description Inhibition of CYP3A4 |
Bioorg Med Chem Lett 21: 3301-6 (2011)
Article DOI: 10.1016/j.bmcl.2011.04.028 BindingDB Entry DOI: 10.7270/Q2P55NVH |
More data for this Ligand-Target Pair | |
72 kDa type IV collagenase
(Homo sapiens (Human)) | BDBM50345520
(CHEMBL1784345 | N-(1-(cyclobutanecarbonyl)-4-((4-(...)Show SMILES Cc1noc(C)c1CCC1CCN(CC1)S(=O)(=O)CC1(CCN(CC1)C(=O)C1CCC1)N(O)C=O Show InChI InChI=1S/C24H38N4O6S/c1-18-22(19(2)34-25-18)7-6-20-8-12-27(13-9-20)35(32,33)16-24(28(31)17-29)10-14-26(15-11-24)23(30)21-4-3-5-21/h17,20-21,31H,3-16H2,1-2H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description Inhibition of recombinant human MMP-2 assessed as substrate cleavage after 20 hrs by fluorescence assay |
Bioorg Med Chem Lett 21: 3301-6 (2011)
Article DOI: 10.1016/j.bmcl.2011.04.028 BindingDB Entry DOI: 10.7270/Q2P55NVH |
More data for this Ligand-Target Pair | |
Collagenase 3
(Homo sapiens (Human)) | BDBM50345520
(CHEMBL1784345 | N-(1-(cyclobutanecarbonyl)-4-((4-(...)Show SMILES Cc1noc(C)c1CCC1CCN(CC1)S(=O)(=O)CC1(CCN(CC1)C(=O)C1CCC1)N(O)C=O Show InChI InChI=1S/C24H38N4O6S/c1-18-22(19(2)34-25-18)7-6-20-8-12-27(13-9-20)35(32,33)16-24(28(31)17-29)10-14-26(15-11-24)23(30)21-4-3-5-21/h17,20-21,31H,3-16H2,1-2H3 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description Inhibition of recombinant human MMP-13 assessed as substrate cleavage after 20 hrs by fluorescence assay |
Bioorg Med Chem Lett 21: 3301-6 (2011)
Article DOI: 10.1016/j.bmcl.2011.04.028 BindingDB Entry DOI: 10.7270/Q2P55NVH |
More data for this Ligand-Target Pair | |
Interstitial collagenase
(Homo sapiens (Human)) | BDBM50345520
(CHEMBL1784345 | N-(1-(cyclobutanecarbonyl)-4-((4-(...)Show SMILES Cc1noc(C)c1CCC1CCN(CC1)S(=O)(=O)CC1(CCN(CC1)C(=O)C1CCC1)N(O)C=O Show InChI InChI=1S/C24H38N4O6S/c1-18-22(19(2)34-25-18)7-6-20-8-12-27(13-9-20)35(32,33)16-24(28(31)17-29)10-14-26(15-11-24)23(30)21-4-3-5-21/h17,20-21,31H,3-16H2,1-2H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description Inhibition of recombinant human MMP-1 assessed as substrate cleavage after 20 hrs by fluorescence assay |
Bioorg Med Chem Lett 21: 3301-6 (2011)
Article DOI: 10.1016/j.bmcl.2011.04.028 BindingDB Entry DOI: 10.7270/Q2P55NVH |
More data for this Ligand-Target Pair | |