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SMILES: [#6]\[#6](-[#6])=[#6]\[#6]-[#6]\[#6](-[#6])=[#6]\[#6]-[#6]\[#6](-[#6])=[#6]\[#6]-[#6]-[#6]-1=[#6]-[#6]-[#6@@H](-[#8]-[#6@@H]-1-[#8])-[#6@@H]-1-[#6]-[#6](=O)-[#7]-[#6]-1=O
InChI Key: InChIKey=DHMXAXCAWHUFET-HVFQXGRFSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Protein kinase C gamma type (Homo sapiens (Human)) | BDBM50345577 (CHEMBL1782082 | Hippolide A) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 6.20E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Second Military Medical University Curated by ChEMBL | Assay Description Binding affinity at PKCgamma after 1 hr by luminescent kinase assay | J Nat Prod 74: 1248-54 (2011) Article DOI: 10.1021/np200227s BindingDB Entry DOI: 10.7270/Q2571CCF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein phosphatase non-receptor type 1 (Homo sapiens (Human)) | BDBM50345577 (CHEMBL1782082 | Hippolide A) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 2.38E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Second Military Medical University Curated by ChEMBL | Assay Description Inhibition of recombinant PTP1B catalytic domain using pNPP as substrate assessed as pNP release | J Nat Prod 74: 1248-54 (2011) Article DOI: 10.1021/np200227s BindingDB Entry DOI: 10.7270/Q2571CCF | |||||||||||
More data for this Ligand-Target Pair |