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SMILES: CCC(O)(CC1C[C@H]2CC[C@H](C1)N2C)c1ccccc1

InChI Key: InChIKey=QLCVMIAFQMBVPR-OWZOALSMSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50345678   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Muscarinic acetylcholine receptor M3


(Homo sapiens (Human))		BDBM50345678
PNG
(1-(endo-8-methyl-8-azabicyclo[3.2.1]octan-3-yl)-2-...)
Show SMILES CCC(O)(CC1C[C@H]2CC[C@H](C1)N2C)c1ccccc1 |r,TLB:13:12:5.6.11:8.9,4:5:12:8.9|
Show InChI InChI=1S/C18H27NO/c1-3-18(20,15-7-5-4-6-8-15)13-14-11-16-9-10-17(12-14)19(16)2/h4-8,14,16-17,20H,3,9-13H2,1-2H3/t16-,17-,18?/m1/s1
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n/an/a 135n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Antagonist activity against human M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR

J Med Chem 52: 5241-52 (2010)


Article DOI: 10.1021/jm900736e
BindingDB Entry DOI: 10.7270/Q2PK0H54
More data for this
Ligand-Target Pair