Found 3 hits for monomerid = 50346026 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Glucokinase/Glucokinase regulatory protein
(Homo sapiens (Human)) | BDBM50346026
((R)-2-(3-chloro-4-(methylsulfonyl)phenyl)-3-((R)-3...)Show SMILES CS(=O)(=O)c1ccc(cc1Cl)[C@@H](C[C@H]1CCC(=O)C1)C(=O)Nc1cnccn1 |r| Show InChI InChI=1S/C19H20ClN3O4S/c1-28(26,27)17-5-3-13(10-16(17)20)15(9-12-2-4-14(24)8-12)19(25)23-18-11-21-6-7-22-18/h3,5-7,10-12,15H,2,4,8-9H2,1H3,(H,22,23,25)/t12-,15+/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL PC cid PC sid PDB UniChem
Patents
Similars
| PDB PubMed
| n/a | n/a | n/a | n/a | 6.32E+3 | n/a | n/a | n/a | n/a |
Servier Research Institute of Medicinal Chemistry
Curated by ChEMBL
| Assay Description Activation of recombinant human glucokinase assessed as NADPH formation using glucose as substrate incubated for 30 mins in presence of NADP+ and glu... |
J Med Chem 59: 687-706 (2016)
BindingDB Entry DOI: 10.7270/Q2CF9S0F |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Glucokinase/Glucokinase regulatory protein
(Homo sapiens (Human)) | BDBM50346026
((R)-2-(3-chloro-4-(methylsulfonyl)phenyl)-3-((R)-3...)Show SMILES CS(=O)(=O)c1ccc(cc1Cl)[C@@H](C[C@H]1CCC(=O)C1)C(=O)Nc1cnccn1 |r| Show InChI InChI=1S/C19H20ClN3O4S/c1-28(26,27)17-5-3-13(10-16(17)20)15(9-12-2-4-14(24)8-12)19(25)23-18-11-21-6-7-22-18/h3,5-7,10-12,15H,2,4,8-9H2,1H3,(H,22,23,25)/t12-,15+/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL PC cid PC sid PDB UniChem
Patents
Similars
| PDB Article PubMed
| n/a | n/a | n/a | 830 | n/a | n/a | n/a | n/a | n/a |
Istituto Italiano di Tecnologia
Curated by ChEMBL
| Assay Description Displacement of TAFMT from human pancreatic N-terminal His6-tagged glucokinase isoform 1 expressed in Escherichia coli BL21(DE3) by stopped-flow fluo... |
J Med Chem 59: 7167-76 (2016)
Article DOI: 10.1021/acs.jmedchem.6b00632 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Glucokinase/Glucokinase regulatory protein
(Homo sapiens (Human)) | BDBM50346026
((R)-2-(3-chloro-4-(methylsulfonyl)phenyl)-3-((R)-3...)Show SMILES CS(=O)(=O)c1ccc(cc1Cl)[C@@H](C[C@H]1CCC(=O)C1)C(=O)Nc1cnccn1 |r| Show InChI InChI=1S/C19H20ClN3O4S/c1-28(26,27)17-5-3-13(10-16(17)20)15(9-12-2-4-14(24)8-12)19(25)23-18-11-21-6-7-22-18/h3,5-7,10-12,15H,2,4,8-9H2,1H3,(H,22,23,25)/t12-,15+/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL PC cid PC sid PDB UniChem
Patents
Similars
| PDB Article PubMed
| n/a | n/a | n/a | n/a | 1.42E+3 | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description Activation of human recombinant glucokinase using 6.5 mM glucose by spectrophotometry |
Bioorg Med Chem Lett 19: 3247-52 (2009)
Article DOI: 10.1016/j.bmcl.2009.04.107 BindingDB Entry DOI: 10.7270/Q2PZ595B |
More data for this Ligand-Target Pair | 3D Structure (crystal) |