BDBM50346035 6-{3,4-Difluoro-5-[(R)-2-hydroxy-3-(2-indan-2-yl-1,1-dimethyl-ethylamino)-propoxy]-phenyl}-tricyclo[3.2.1.0*2,4*]octane-3-carboxylic acid::CHEMBL1783762
SMILES: CC(C)(CC1Cc2ccccc2C1)NC[C@@H](O)COc1cc(cc(F)c1F)C1CC2CC1C1C2C1C(O)=O
InChI Key: InChIKey=FGLWBYWIJLRPSI-IYBOAGAWSA-N
Data: 1 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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Calcium-sensing receptor (CaSR) (Homo sapiens (Human)) | BDBM50346035 (6-{3,4-Difluoro-5-[(R)-2-hydroxy-3-(2-indan-2-yl-1...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 56 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc. Curated by ChEMBL | Assay Description Negative allosteric modulator activity at human recombinant calcium sensing receptor expressed in HEK cells | Bioorg Med Chem Lett 19: 3328-32 (2009) Article DOI: 10.1016/j.bmcl.2009.04.044 BindingDB Entry DOI: 10.7270/Q2K937V7 | |||||||||||
More data for this Ligand-Target Pair |