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SMILES: Cc1ccc(CC(C)(C)NC[C@@H](O)COc2cccc(c2)C2CC3CC2C2C3C2C(O)=O)cc1F

InChI Key: InChIKey=OMEWJWUGGRDZKF-WREGFGOOSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50346040   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Extracellular calcium-sensing receptor


(Homo sapiens (Human))		BDBM50346040
PNG
(6-(3-{(R)-3-[2-(3-Fluoro-4-methyl-phenyl)-1,1-dime...)
Show SMILES Cc1ccc(CC(C)(C)NC[C@@H](O)COc2cccc(c2)C2CC3CC2C2C3C2C(O)=O)cc1F |r|
Show InChI InChI=1S/C29H36FNO4/c1-16-7-8-17(9-24(16)30)13-29(2,3)31-14-20(32)15-35-21-6-4-5-18(10-21)22-11-19-12-23(22)26-25(19)27(26)28(33)34/h4-10,19-20,22-23,25-27,31-32H,11-15H2,1-3H3,(H,33,34)/t19?,20-,22?,23?,25?,26?,27?/m1/s1
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Article
PubMed
n/an/a 3.50E+3n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Negative allosteric modulator activity at human recombinant calcium sensing receptor expressed in HEK cells

Bioorg Med Chem Lett 19: 3328-32 (2009)


Article DOI: 10.1016/j.bmcl.2009.04.044
BindingDB Entry DOI: 10.7270/Q2K937V7
More data for this
Ligand-Target Pair