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SMILES: CCc1c(C)nc(nc1Nc1ccc(cc1)C(O)=O)-c1ccccc1

InChI Key: InChIKey=JFLSLZLXRTWYJW-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50346091   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM50346091 (4-(5-ethyl-6-methyl-2-phenylpyrimidin-4-ylamino)be...) Show SMILES CCc1c(C)nc(nc1Nc1ccc(cc1)C(O)=O)-c1ccccc1 Show InChI InChI=1S/C20H19N3O2/c1-3-17-13(2)21-18(14-7-5-4-6-8-14)23-19(17)22-16-11-9-15(10-12-16)20(24)25/h4-12H,3H2,1-2H3,(H,24,25)(H,21,22,23)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	140	n/a	n/a	n/a	n/a	n/a	n/a
Asahi Kasei Pharma Corporation Curated by ChEMBL					Assay Description Inhibition of human PDE4B1 incubated for 10 mins using cAMP and [3H]cAMP substrates				Bioorg Med Chem Lett 19: 3174-6 (2009) Article DOI: 10.1016/j.bmcl.2009.04.121 BindingDB Entry DOI: 10.7270/Q26110NQ
					More data for this Ligand-Target Pair
Retinoic acid receptor RXR-alpha (Homo sapiens (Human))	BDBM50346091 (4-(5-ethyl-6-methyl-2-phenylpyrimidin-4-ylamino)be...) Show SMILES CCc1c(C)nc(nc1Nc1ccc(cc1)C(O)=O)-c1ccccc1 Show InChI InChI=1S/C20H19N3O2/c1-3-17-13(2)21-18(14-7-5-4-6-8-14)23-19(17)22-16-11-9-15(10-12-16)20(24)25/h4-12H,3H2,1-2H3,(H,24,25)(H,21,22,23)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	US Patent	n/a	n/a	n/a	n/a	5.00E+3	n/a	n/a	n/a	n/a
TBA US Patent					Assay Description The in vitro transactivation assay determined the capacity of the compounds of the invention to activate the Nurr1:RXR heterodimers. Naive SHSY-5Y ce...				US Patent US10946019 (2021)
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4D (Homo sapiens (Human))	BDBM50346091 (4-(5-ethyl-6-methyl-2-phenylpyrimidin-4-ylamino)be...) Show SMILES CCc1c(C)nc(nc1Nc1ccc(cc1)C(O)=O)-c1ccccc1 Show InChI InChI=1S/C20H19N3O2/c1-3-17-13(2)21-18(14-7-5-4-6-8-14)23-19(17)22-16-11-9-15(10-12-16)20(24)25/h4-12H,3H2,1-2H3,(H,24,25)(H,21,22,23)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
Asahi Kasei Pharma Corporation Curated by ChEMBL					Assay Description Inhibition of human PDE4D3 incubated for 10 mins using cAMP and [3H]cAMP substrates				Bioorg Med Chem Lett 19: 3174-6 (2009) Article DOI: 10.1016/j.bmcl.2009.04.121 BindingDB Entry DOI: 10.7270/Q26110NQ
					More data for this Ligand-Target Pair