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SMILES: CC(C)c1nc(nc(Nc2ccc(cc2)C(O)=O)c1CC=C)-c1ccccc1

InChI Key: InChIKey=VCXNFBIOGNEURL-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50346101   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))		BDBM50346101
PNG
(4-(5-allyl-6-isopropyl-2-phenylpyrimidin-4-ylamino...)
Show SMILES CC(C)c1nc(nc(Nc2ccc(cc2)C(O)=O)c1CC=C)-c1ccccc1
Show InChI InChI=1S/C23H23N3O2/c1-4-8-19-20(15(2)3)25-21(16-9-6-5-7-10-16)26-22(19)24-18-13-11-17(12-14-18)23(27)28/h4-7,9-15H,1,8H2,2-3H3,(H,27,28)(H,24,25,26)
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Article
PubMed
n/an/a>1.00E+3n/an/an/an/an/an/a



Asahi Kasei Pharma Corporation

Curated by ChEMBL


Assay Description
Inhibition of human PDE4B1 incubated for 10 mins using cAMP and [3H]cAMP substrates

Bioorg Med Chem Lett 19: 3174-6 (2009)


Article DOI: 10.1016/j.bmcl.2009.04.121
BindingDB Entry DOI: 10.7270/Q26110NQ
More data for this
Ligand-Target Pair