BDBM50346276 CHEMBL1782549::sodium(3R,5R)-7-(4-(benzylcarbamoyl)-2-(4-fluorophenyl)-5-propyl-1H-imidazol-1-yl)-3,5-dihydroxyheptanoate

SMILES: CCCc1c(nc(-c2ccc(F)cc2)n1CC[C@@H](O)C[C@@H](O)CC([O-])=O)C(=O)NCc1ccccc1

InChI Key: InChIKey=JIVQMHYHCHVBAN-FGZHOGPDSA-M

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50346276   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
HMG-CoA reductase (Rattus norvegicus (rat))	BDBM50346276 (CHEMBL1782549 | sodium(3R,5R)-7-(4-(benzylcarbamoy...) Show SMILES CCCc1c(nc(-c2ccc(F)cc2)n1CC[C@@H](O)C[C@@H](O)CC([O-])=O)C(=O)NCc1ccccc1 |r| Show InChI InChI=1S/C27H32FN3O5/c1-2-6-23-25(27(36)29-17-18-7-4-3-5-8-18)30-26(19-9-11-20(28)12-10-19)31(23)14-13-21(32)15-22(33)16-24(34)35/h3-5,7-12,21-22,32-33H,2,6,13-17H2,1H3,(H,29,36)(H,34,35)/p-1/t21-,22-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	26	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of HMG-CoA reductase in Sprague-Dawley rat liver microsomes using using [14C]HMG-CoA as substrate preincubated for 0.5 hrs before substrat...				Bioorg Med Chem Lett 21: 2725-31 (2011) Article DOI: 10.1016/j.bmcl.2010.11.103 BindingDB Entry DOI: 10.7270/Q2H995J1
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