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BDBM50346280 CHEMBL1782553::sodium(3R,5R)-7-(5-cyclopropyl-2-(4-fluorophenyl)-4-(3-methylbenzylcarbamoyl)-1H-imidazol-1-yl)-3,5-dihydroxyheptanoate

SMILES: Cc1cccc(CNC(=O)c2nc(-c3ccc(F)cc3)n(CC[C@@H](O)C[C@@H](O)CC([O-])=O)c2C2CC2)c1

InChI Key: InChIKey=UQBCYNDLQBAWMG-DHIUTWEWSA-M

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50346280   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
HMG-CoA reductase


(Rattus norvegicus (rat))
BDBM50346280
PNG
(CHEMBL1782553 | sodium(3R,5R)-7-(5-cyclopropyl-2-(...)
Show SMILES Cc1cccc(CNC(=O)c2nc(-c3ccc(F)cc3)n(CC[C@@H](O)C[C@@H](O)CC([O-])=O)c2C2CC2)c1 |r|
Show InChI InChI=1S/C28H32FN3O5/c1-17-3-2-4-18(13-17)16-30-28(37)25-26(19-5-6-19)32(12-11-22(33)14-23(34)15-24(35)36)27(31-25)20-7-9-21(29)10-8-20/h2-4,7-10,13,19,22-23,33-34H,5-6,11-12,14-16H2,1H3,(H,30,37)(H,35,36)/p-1/t22-,23-/m1/s1
PDB
MMDB

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PC cid
PC sid
UniChem
Article
PubMed
n/an/a 7.20n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of HMG-CoA reductase in Sprague-Dawley rat liver microsomes using using [14C]HMG-CoA as substrate preincubated for 0.5 hrs before substrat...


Bioorg Med Chem Lett 21: 2725-31 (2011)


Article DOI: 10.1016/j.bmcl.2010.11.103
BindingDB Entry DOI: 10.7270/Q2H995J1
More data for this
Ligand-Target Pair