BDBM50346281 CHEMBL1782554::sodium(3R,5R)-7-(5-cyclopropyl-2-(4-fluorophenyl)-4-(2-methylbenzylcarbamoyl)-1H-imidazol-1-yl)-3,5-dihydroxyheptanoate

SMILES: Cc1ccccc1CNC(=O)c1nc(-c2ccc(F)cc2)n(CC[C@@H](O)C[C@@H](O)CC([O-])=O)c1C1CC1

InChI Key: InChIKey=GWUOIDODGYKLIT-DHIUTWEWSA-M

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50346281   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
3-hydroxy-3-methylglutaryl-coenzyme A reductase (Rattus norvegicus (rat))	BDBM50346281 (CHEMBL1782554 | sodium(3R,5R)-7-(5-cyclopropyl-2-(...) Show SMILES Cc1ccccc1CNC(=O)c1nc(-c2ccc(F)cc2)n(CC[C@@H](O)C[C@@H](O)CC([O-])=O)c1C1CC1 |r| Show InChI InChI=1S/C28H32FN3O5/c1-17-4-2-3-5-20(17)16-30-28(37)25-26(18-6-7-18)32(13-12-22(33)14-23(34)15-24(35)36)27(31-25)19-8-10-21(29)11-9-19/h2-5,8-11,18,22-23,33-34H,6-7,12-16H2,1H3,(H,30,37)(H,35,36)/p-1/t22-,23-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.90	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of HMG-CoA reductase in Sprague-Dawley rat liver microsomes using using [14C]HMG-CoA as substrate preincubated for 0.5 hrs before substrat...				Bioorg Med Chem Lett 21: 2725-31 (2011) Article DOI: 10.1016/j.bmcl.2010.11.103 BindingDB Entry DOI: 10.7270/Q2H995J1
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