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SMILES: CN(C)S(=O)(=O)c1ccc(CNC(=O)c2nc(-c3ccc(F)cc3)n(CC[C@@H](O)C[C@@H](O)CC([O-])=O)c2C2CC2)cc1

InChI Key: InChIKey=BBKCAKPNCLOJQV-DHIUTWEWSA-M

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50346293   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
3-hydroxy-3-methylglutaryl-coenzyme A reductase


(Rattus norvegicus (rat))		BDBM50346293
PNG
(CHEMBL1782565 | sodium(3R,5R)-7-(5-cyclopropyl-4-(...)
Show SMILES CN(C)S(=O)(=O)c1ccc(CNC(=O)c2nc(-c3ccc(F)cc3)n(CC[C@@H](O)C[C@@H](O)CC([O-])=O)c2C2CC2)cc1 |r|
Show InChI InChI=1S/C29H35FN4O7S/c1-33(2)42(40,41)24-11-3-18(4-12-24)17-31-29(39)26-27(19-5-6-19)34(14-13-22(35)15-23(36)16-25(37)38)28(32-26)20-7-9-21(30)10-8-20/h3-4,7-12,19,22-23,35-36H,5-6,13-17H2,1-2H3,(H,31,39)(H,37,38)/p-1/t22-,23-/m1/s1
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Article
PubMed
n/an/a 4.90n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of HMG-CoA reductase in Sprague-Dawley rat liver microsomes using using [14C]HMG-CoA as substrate preincubated for 0.5 hrs before substrat...

Bioorg Med Chem Lett 21: 2725-31 (2011)


Article DOI: 10.1016/j.bmcl.2010.11.103
BindingDB Entry DOI: 10.7270/Q2H995J1
More data for this
Ligand-Target Pair