BDBM50347117 CHEMBL1797220

SMILES: Cc1cc(OCc2ccc(F)cc2F)c(Br)c(=O)n1-c1cccc(CNC(=O)CN)c1

InChI Key: InChIKey=MNWSLSMYDZPEOK-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50347117   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM50347117 (CHEMBL1797220) Show SMILES Cc1cc(OCc2ccc(F)cc2F)c(Br)c(=O)n1-c1cccc(CNC(=O)CN)c1 Show InChI InChI=1S/C22H20BrF2N3O3/c1-13-7-19(31-12-15-5-6-16(24)9-18(15)25)21(23)22(30)28(13)17-4-2-3-14(8-17)11-27-20(29)10-26/h2-9H,10-12,26H2,1H3,(H,27,29)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	261	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of p38alpha assessed as phosphorylation of fluorescently-labelled MK2 using Hsp27 peptide as substrate after 60 mins by fluorescence assay				Bioorg Med Chem Lett 21: 4059-65 (2011) Article DOI: 10.1016/j.bmcl.2011.04.120 BindingDB Entry DOI: 10.7270/Q25Q4WFH
					More data for this Ligand-Target Pair