BDBM50347122 CHEMBL1797225

SMILES: CNC(=O)c1ccc(cc1)-n1c(C)cc(OCc2ccc(F)cc2F)c(Br)c1=O

InChI Key: InChIKey=FYYYZUBSDRZBNG-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50347122   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM50347122 (CHEMBL1797225) Show SMILES CNC(=O)c1ccc(cc1)-n1c(C)cc(OCc2ccc(F)cc2F)c(Br)c1=O Show InChI InChI=1S/C21H17BrF2N2O3/c1-12-9-18(29-11-14-3-6-15(23)10-17(14)24)19(22)21(28)26(12)16-7-4-13(5-8-16)20(27)25-2/h3-10H,11H2,1-2H3,(H,25,27)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	126	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of p38alpha assessed as phosphorylation of fluorescently-labelled MK2 using Hsp27 peptide as substrate after 60 mins by fluorescence assay				Bioorg Med Chem Lett 21: 4059-65 (2011) Article DOI: 10.1016/j.bmcl.2011.04.120 BindingDB Entry DOI: 10.7270/Q25Q4WFH
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