BDBM50347987 CHEMBL1800153

SMILES: COCCN(C)Cc1c(sc2n(Cc3c(F)cccc3F)c(=O)n(-c3ccc(C)cn3)c(=O)c12)-c1ccc(NC(=O)NOC)cc1

InChI Key: InChIKey=HCJYDJMLQMLSAN-UHFFFAOYSA-N

Data: 4 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50347987   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Gonadotropin-releasing hormone receptor (Homo sapiens (Human))	BDBM50347987 (CHEMBL1800153) Show SMILES COCCN(C)Cc1c(sc2n(Cc3c(F)cccc3F)c(=O)n(-c3ccc(C)cn3)c(=O)c12)-c1ccc(NC(=O)NOC)cc1 Show InChI InChI=1S/C32H32F2N6O5S/c1-19-8-13-26(35-16-19)40-29(41)27-23(17-38(2)14-15-44-3)28(20-9-11-21(12-10-20)36-31(42)37-45-4)46-30(27)39(32(40)43)18-22-24(33)6-5-7-25(22)34/h5-13,16H,14-15,17-18H2,1-4H3,(H2,36,37,42)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.30	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company, Ltd. Curated by ChEMBL					Assay Description Antagonist activity at human GnRH receptor expressed in CHO cells assessed as inhibition of GnRH-induced arachadonic acid release using [5,6,8,9,11,1...				J Med Chem 54: 4998-5012 (2011) Article DOI: 10.1021/jm200216q BindingDB Entry DOI: 10.7270/Q22N52MK
					More data for this Ligand-Target Pair
Gonadotropin-releasing hormone receptor (Homo sapiens (Human))	BDBM50347987 (CHEMBL1800153) Show SMILES COCCN(C)Cc1c(sc2n(Cc3c(F)cccc3F)c(=O)n(-c3ccc(C)cn3)c(=O)c12)-c1ccc(NC(=O)NOC)cc1 Show InChI InChI=1S/C32H32F2N6O5S/c1-19-8-13-26(35-16-19)40-29(41)27-23(17-38(2)14-15-44-3)28(20-9-11-21(12-10-20)36-31(42)37-45-4)46-30(27)39(32(40)43)18-22-24(33)6-5-7-25(22)34/h5-13,16H,14-15,17-18H2,1-4H3,(H2,36,37,42)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	0.100	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company, Ltd. Curated by ChEMBL					Assay Description Displacement of [125I]leuprorelin from recombinant human GnRH receptor expressed in CHO cells after 60 mins by X-ray counter				J Med Chem 54: 4998-5012 (2011) Article DOI: 10.1021/jm200216q BindingDB Entry DOI: 10.7270/Q22N52MK
					More data for this Ligand-Target Pair
Gonadotropin-releasing hormone receptor (Homo sapiens (Human))	BDBM50347987 (CHEMBL1800153) Show SMILES COCCN(C)Cc1c(sc2n(Cc3c(F)cccc3F)c(=O)n(-c3ccc(C)cn3)c(=O)c12)-c1ccc(NC(=O)NOC)cc1 Show InChI InChI=1S/C32H32F2N6O5S/c1-19-8-13-26(35-16-19)40-29(41)27-23(17-38(2)14-15-44-3)28(20-9-11-21(12-10-20)36-31(42)37-45-4)46-30(27)39(32(40)43)18-22-24(33)6-5-7-25(22)34/h5-13,16H,14-15,17-18H2,1-4H3,(H2,36,37,42)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	0.180	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company, Ltd. Curated by ChEMBL					Assay Description Antagonist activity at human GnRH receptor expressed in CHO cells assessed as inhibition of GnRH-induced arachadonic acid release using [5,6,8,9,11,1...				J Med Chem 54: 4998-5012 (2011) Article DOI: 10.1021/jm200216q BindingDB Entry DOI: 10.7270/Q22N52MK
					More data for this Ligand-Target Pair
Gonadotropin-releasing hormone receptor (Homo sapiens (Human))	BDBM50347987 (CHEMBL1800153) Show SMILES COCCN(C)Cc1c(sc2n(Cc3c(F)cccc3F)c(=O)n(-c3ccc(C)cn3)c(=O)c12)-c1ccc(NC(=O)NOC)cc1 Show InChI InChI=1S/C32H32F2N6O5S/c1-19-8-13-26(35-16-19)40-29(41)27-23(17-38(2)14-15-44-3)28(20-9-11-21(12-10-20)36-31(42)37-45-4)46-30(27)39(32(40)43)18-22-24(33)6-5-7-25(22)34/h5-13,16H,14-15,17-18H2,1-4H3,(H2,36,37,42)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	0.300	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company, Ltd. Curated by ChEMBL					Assay Description Displacement of [125I]leuprorelin from recombinant human GnRH receptor expressed in CHO cells after 60 mins by X-ray counter in presence of 40% fetal...				J Med Chem 54: 4998-5012 (2011) Article DOI: 10.1021/jm200216q BindingDB Entry DOI: 10.7270/Q22N52MK
					More data for this Ligand-Target Pair