BDBM50348427 CHEMBL1800960::US9492405, 49
SMILES: CC[C@@H](Cc1ccc(O)cc1)NC[C@H](O)c1cc(O)cc(O)c1
InChI Key: InChIKey=KFRXJKMLZFERKO-KSSFIOAISA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Beta-2 adrenergic receptor (Homo sapiens (Human)) | BDBM50348427 (CHEMBL1800960 | US9492405, 49) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 294 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Medical University of Lublin Curated by ChEMBL | Assay Description Displacement of [3H]-(R,R')-methoxyfenoterol from human beta2 adrenergic receptor expressed in HEK cells by liquid scintillation counting analysis | Bioorg Med Chem 22: 234-46 (2014) Article DOI: 10.1016/j.bmc.2013.11.030 BindingDB Entry DOI: 10.7270/Q2251N5F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-2 adrenergic receptor (Homo sapiens (Human)) | BDBM50348427 (CHEMBL1800960 | US9492405, 49) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 294 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Medical University of Lublin Curated by ChEMBL | Assay Description Displacement of [3H]-(R,R')-methoxyfenoterol from human beta2 adrenergic receptor expressed in HEK cells by liquid scintillation counting analysis | Bioorg Med Chem 22: 234-46 (2014) Article DOI: 10.1016/j.bmc.2013.11.030 BindingDB Entry DOI: 10.7270/Q2251N5F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-2 adrenergic receptor (Homo sapiens (Human)) | BDBM50348427 (CHEMBL1800960 | US9492405, 49) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 5.76E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Medical University of Lublin Curated by ChEMBL | Assay Description Displacement of [3H]CGP-12177 from human beta2-adrenergic receptor expressed in HEK 293 cells | Bioorg Med Chem 18: 728-36 (2010) Article DOI: 10.1016/j.bmc.2009.11.062 BindingDB Entry DOI: 10.7270/Q2R78FJF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-1 adrenergic receptor (Rattus norvegicus (Rat)) | BDBM50348427 (CHEMBL1800960 | US9492405, 49) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 1.17E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Medical University of Lublin Curated by ChEMBL | Assay Description Displacement of [3H]CGP-12177 from beta1-adrenergic receptor in Sprague-Dawley rat cortical membrane after 2 hrs | Bioorg Med Chem 18: 728-36 (2010) Article DOI: 10.1016/j.bmc.2009.11.062 BindingDB Entry DOI: 10.7270/Q2R78FJF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-2 adrenergic receptor (Homo sapiens (Human)) | BDBM50348427 (CHEMBL1800960 | US9492405, 49) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | US Patent | n/a | n/a | 17.9 | n/a | n/a | n/a | n/a | n/a | 37 |
The United States of America, as represented by the Secretary, Department of Health and Human Services; SRI International US Patent | Assay Description To measure beta2-AR mediated inhibition of mitogenesis, HEK-beta2-AR, 1321N1 or U87MG cells were seeded in a 96-well plate at approximately 5,000 c... | US Patent US9492405 (2016) BindingDB Entry DOI: 10.7270/Q2CJ8CBM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-2 adrenergic receptor (Homo sapiens (Human)) | BDBM50348427 (CHEMBL1800960 | US9492405, 49) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 17 | n/a | n/a | n/a | n/a |
Medical University of Lublin Curated by ChEMBL | Assay Description Agonist activity at human beta2 adrenergic receptor expressed in HEK 293 cells assessed as stimulation of cAMP accumulation by protein kinase binding... | Bioorg Med Chem 18: 728-36 (2010) Article DOI: 10.1016/j.bmc.2009.11.062 BindingDB Entry DOI: 10.7270/Q2R78FJF | |||||||||||
More data for this Ligand-Target Pair |